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Open Access Research article

A pri-miR-218 variant and risk of cervical carcinoma in Chinese women

Ting-Yan Shi15, Xiao-Jun Chen25, Mei-Ling Zhu15, Meng-Yun Wang15, Jing He15, Ke-Da Yu35, Zhi-Ming Shao135, Meng-Hong Sun45, Xiao-Yan Zhou45, Xi Cheng25, Xiaohua Wu25* and Qingyi Wei16*

Author Affiliations

1 Cancer Institute, Fudan University Shanghai Cancer Center, Shanghai, China

2 Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China

3 Department of Breast Surgery, Fudan University Shanghai Cancer Center, Shanghai, China

4 Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China

5 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China

6 Department of Epidemiology, The University of Texas M.D, Anderson Cancer Center, Houston, Texas, USA

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BMC Cancer 2013, 13:19  doi:10.1186/1471-2407-13-19

Published: 15 January 2013

Abstract

Background

MicroRNA (miRNA)-related single nucleotide polymorphisms (SNPs) may compromise miRNA binding affinity and modify mRNA expression levels of the target genes, thus leading to cancer susceptibility. However, few studies have investigated roles of miRNA-related SNPs in the etiology of cervical carcinoma.

Methods

In this case–control study of 1,584 cervical cancer cases and 1,394 cancer-free female controls, we investigated associations between two miR-218-related SNPs involved in the LAMB3-miR-218 pathway and the risk of cervical carcinoma in Eastern Chinese women.

Results

We found that the pri-miR-218 rs11134527 variant GG genotype was significantly associated with a decreased risk of cervical carcinoma compared with AA/AG genotypes (adjusted OR=0.77, 95% CI=0.63-0.95, P=0.015). However, this association was not observed for the miR-218 binding site SNP (rs2566) on LAMB3. Using the multifactor dimensionality reduction analysis, we observed some evidence of interactions of these two SNPs with other risk factors, especially age at primiparity and menopausal status, in the risk of cervical carcinoma.

Conclusions

The pri-miR-218 rs11134527 SNP was significantly associated with the risk of cervical carcinoma in Eastern Chinese women. Larger, independent studies are warranted to validate our findings.

Keywords:
Case–control study; Cervical cancer; LAMB3-miR-218 pathway; Polymorphism; Genetic susceptibility