Table 2

Genes down regulated in SK-NEP-1 cells treated with YM155 compared with DMSO control group
Gene Symbol +DMSO +YM155 Ratio P value
1 HIPK2 Homeodomain interacting protein kinase 2 31.640 11.619 0.367 0.0353
2 CD27 CD27 molecule 1.462 0.538 0.368 0.0353
3 PCBP4 Poly(rC) binding protein 4 9.419 3.481 0.370 0.0334
4 PAK7 P21 protein (Cdc42/Rac)-activated kinase 7 0.120 0.044 0.370 0.0334
5 PPP1R13B Protein phosphatase 1, regulatory subunit 13B 75.280 27.926 0.371 0.0322
6 TP73 Tumor protein p73 9.738 3.619 0.372 0.0321
7 RASA1 RAS p21 protein activator 1 138.406 49.465 0.357 0.0315
8 CRYAA Crystallin, alpha A 0.210 0.079 0.375 0.0272
9 TIAF1 TGFB1-induced anti-apoptotic factor 1 243.057 91.076 0.375 0.0242
10 CARD14 Caspase recruitment domain family, member 14 37.791 13.412 0.355 0.0241
11 NOD1 Nucleotide-binding domain containing 1 163.081 61.858 0.379 0.0214
12 TNFRSF1B Tumor necrosis factor receptor superfamily 1B 45.110 17.323 0.384 0.0174
13 HIP1 Huntingtin interacting protein 1 14.568 4.941 0.339 0.0174
14 UTP11L UTP11-like, U3 small nucleolar ribonucleoprotein 267.624 104.245 0.390 0.0118
15 SPP1 Secreted phosphoprotein 1 2.389 0.801 0.335 0.0107
16 NME5 NME/NM23 family member 5 0.217 0.073 0.335 0.0092
17 MYO18A Myosin XVIIIA 164.894 54.821 0.332 0.0087
18 PPP2R1B Protein phosphatase 2, regulatory subunit A 9.768 3.887 0.398 0.0033
19 BAG1 BCL2-associated athanogene 70.273 28.001 0.398 0.0033
20 DAPK2 Death-associated protein kinase 2 1.549 0.509 0.329 0.0023
21 TNFSF10 Tumor necrosis factor (ligand) superfamily 10 2.596 0.844 0.325 0.0022
22 TNFRSF25 Tumor necrosis factor receptor superfamily 25 10.685 4.340 0.406 0.0022
23 FOXL2 Forkhead box L2 11.954 4.886 0.409 0.0021
24 CASP10 Caspase 10, apoptosis-related cysteine peptidase 13.465 4.252 0.316 0.0021
25 CARD8 Caspase recruitment domain family, member 8 3.835 1.209 0.315 0.0020
26 ALOX12 Arachidonate 12-lipoxygenase 9.725 3.039 0.312 0.0020
27 OPA1 Optic atrophy 1 (autosomal dominant) 172.500 71.720 0.416 0.0020
28 ERN2 Endoplasmic reticulum to nucleus signaling 2 2.851 1.187 0.416 0.0020
29 STK17A Serine/threonine kinase 17a 111.835 46.583 0.417 0.0020
30 CARD9 Caspase recruitment domain family, member 9 5.195 1.578 0.304 0.0020
31 GRM4 Glutamate receptor, metabotropic 4 0.958 0.408 0.426 0.0020
32 SON SON DNA binding protein 547.934 234.409 0.428 0.0019
33 PLAGL2 Pleiomorphic adenoma gene-like 2 69.972 30.027 0.429 0.0019
34 BIRC5 Baculoviral IAP repeat containing 5 59.315 25.502 0.430 0.0019
35 FADD Fas (TNFRSF6)-associated via death domain 323.082 93.703 0.290 0.0019
36 NAIP NLR family, apoptosis inhibitory protein 44.019 12.731 0.289 0.0008
37 BCL2 B-cell CLL/lymphoma 2 6.950 3.020 0.435 0.0008
38 ZNF443 Zinc finger protein 443 8.149 3.583 0.440 0.0003
39 CASP8AP2 Caspase 8 associated protein 2 43.673 19.445 0.445 0.0003
40 CUL5 Cullin 5 134.969 60.117 0.445 0.0002
41 DAPK1 Death-associated protein kinase 1 15.806 4.237 0.268 <0.0001
42 NKX3-2 NK3 homeobox 2 0.830 0.371 0.447 <0.0001
43 SEMA4D Itransmembrane domain semaphoring 4D 9.709 2.589 0.267 <0.0001
44 SST Somatostatin 0.694 0.179 0.258 <0.0001
45 ALOX15B Arachidonate 15-lipoxygenase, type B 0.263 0.063 0.242 <0.0001
46 NOTCH2 Notch 2 930.886 223.933 0.241 <0.0001
47 NLRC4 NLR family, CARD domain containing 4 20.624 4.653 0.226 <0.0001
48 PRKCA Protein kinase C, alpha 30.560 6.439 0.211 <0.0001
49 APOE Apolipoprotein E 1.075 0.210 0.195 <0.0001
50 NTF3 Neurotrophin 3 0.295 0.044 0.150 <0.0001
51 CARD17 Caspase recruitment domain family, member 17 0.363 0.047 0.131 <0.0001
52 MAPK8IP2 Mitogen kinase 8 interacting protein 2 0.432 0.049 0.114 <0.0001
53 F2 coagulation factor II 3.794 0.104 0.027 <0.0001
54 CUL3 cullin 3 1.228 0.059 0.048 <0.0001

Tao et al.

Tao et al. BMC Cancer 2012 12:619   doi:10.1186/1471-2407-12-619

Open Data