Association between family members of dialysis patients and chronic kidney disease: a multicenter study in China
1 Renal Division, Department of Medicine, Peking University First Hospital; Peking University Institute of Nephrology; Key Laboratory of Renal Disease, Ministry of Health of China; Key Laboratory of Chronic Kidney Disease Prevention and Treatment (Peking University), Ministry of Education, 8 Xishiku Street, Xicheng District, Beijing, 100034, China
2 Department of Nephrology, Qianfoshan Hospital, Shandong University, Jinan, China
3 Dialysis and Transplantation Centers, The Third Central Hospital, Tianjin, China
4 Department of Nephrology, Beijing ChaoYang Hospital, Beijing, China
5 Department of Nephrology, China-Japan Friendship Hospital, Beijing, China
6 Department of Nephrology, Peking University People’s Hospital, Beijing, China
7 Department of Nephrology, The General Hospital of Chinese People’s Liberation Army, Beijing, China
8 Department of Nephrology, The Second Hospital, Tianjin Medical University, Tianjin, China
9 The Blood Purification Center, Tianjin People’s Hospital, TianJin, China
10 Department of Nephrology, The Fourth Hospital, HeBei Medical University, ShiJia Zhuang, China
11 Department of Nephrology, The First Hospital, Dalian Medical University, Dalian, China
12 The Blood Purification Center, Beijing ChaoYang Hospital, Beijing, China
13 Department of Nephrology, TongRen Hospital, Capital Medical University, Beijing, China
14 Department of Nephrology, The Central Hospital of China Aerospace Corporation, Beijing, China
15 Department of Nephrology, The Beijing Shiji Tan Hospital, Beijing, China
16 Department of Nephrology, Dongzhi Men Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China
17 Department of Nephrology, Beijing Hospital, Beijing, China
18 Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, China
BMC Nephrology 2013, 14:19 doi:10.1186/1471-2369-14-19Published: 18 January 2013
Family members of patients with end stage renal disease were reported to have an increased prevalence of chronic kidney disease (CKD). However, studies differentiated genetic and non-genetic family members are limited. We sought to investigate the prevalence of CKD among fist-degree relatives and spouses of dialysis patients in China.
Seventeen dialysis facilities from 4 cities of China including 1062 first-degree relatives and 450 spouses of dialysis patients were enrolled. Sex- and age- matched controls were randomly selected from a representative sample of general population in Beijing. CKD was defined as decreased estimated glomerular (eGFR < 60 mL/min/1.73 m2) or albuminuria.
The prevalence of eGFR less than 60 mL/min/1.73 m2, albuminuria and the overall prevalence of CKD in dialysis spouses were compared with their counterpart controls, which was 3.8% vs. 7.8% (P < 0.01), 16.8% vs. 14.6% (P = 0.29) and 18.4% vs. 19.8% (P = 0.61), respectively. The prevalence of eGFR less than 60 mL/min/1.73 m2, albuminuria and the overall prevalence of CKD in dialysis relatives were also compared with their counterpart controls, which was 1.5% vs. 2.4% (P = 0.12), 14.4% vs. 8.4% (P < 0.01) and 14.6% vs. 10.5% (P < 0.01), respectively. Multivariable Logistic regression analysis indicated that being spouses of dialysis patients is negatively associated with presence of low eGFR, and being relatives of dialysis patients is positively associated with presence of albuminuria.
The association between being family members of dialysis patients and presence of CKD is different between first-degree relatives and spouses. The underlying mechanisms deserve further investigation.