Challenge of conducting a placebo-controlled randomized efficacy study for influenza vaccine in a season with low attack rate and a mismatched vaccine B strain: a concrete example

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Jiří Beran^*, Veronika Wertzova, Karel Honegr, Eva Kaliskova, Martina Havlickova, Jiří Havlik, Helena Jirincova, Pascale Van Belle, Varsha Jain, Bruce Innis and Jeanne-Marie Devaster