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Challenge of conducting a placebo-controlled randomized efficacy study for influenza vaccine in a season with low attack rate and a mismatched vaccine B strain: a concrete example

Jiří Beran*, Veronika Wertzova, Karel Honegr, Eva Kaliskova, Martina Havlickova, Jiří Havlik, Helena Jirincova, Pascale Van Belle, Varsha Jain, Bruce Innis and Jeanne-Marie Devaster

BMC Infectious Diseases 2009, 9:2 doi:10.1186/1471-2334-9-2

Pre-publication versions of this article and reviewers' reports

Original Submission - Version 1 Manuscript 09 Oct 2008
Resubmission - Version 2 Manuscript 09 Oct 2008
Reviewer's Report Jodie McVernon 31 Oct 2008
Reviewer's Report Tom Jefferson 03 Nov 2008
Reviewer's Report Suzanne Ohmit 05 Nov 2008
Reviewer's Report Fred Aoki 07 Nov 2008
Resubmission - Version 3 Manuscript Author's comment 16 Dec 2008
Editorial acceptance 29 Dec 2008
Published 17 Jan 2009