Table 2

Validation by RNA interference data

Role

TF

# of target genes

# of genes verified in RNAi

Chi-Square

P-value


Activation

Nanog

39

9

9.710604

0.00183

Sox2

121

20

16.22083

5.6E-05

Oct4

67

13

25.26604

5E-07

Esrrb

95

6

2.966206

0.085021

Tcl1

21

2

4.650429

0.03105

Klf4

49

16

25.21262

5.1E-07


Repression

Nanog

47

2

0.018713

0.891192

Sox2

132

12

9.035917

0.00265

Oct4

103

7

3.909397

0.04802

Esrrb

73

6

5.407721

0.02005

Tcl1

27

2

4.663594

0.03081

Klf4

62

10

0.537394

0.463515


Chen and Zhong BMC Genomics 2008 9(Suppl 2):S19   doi:10.1186/1471-2164-9-S2-S19

Open Data