Examples of structurally divergent MoRFs. MoRFs (red ribbons) and partners (green surface) are shown (A) An α-MoRF, Proteinase Inhibitor IA3, bound to Proteinase A (PDB entry 1DP5). (B) A β-MoRF, viral protein pVIc, bound to Human Adenovirus 2 Proteinase (PDB entry 1AVP). (C) An ι-MoRF, Amphiphysin, bound to α-adaptin C (PDB entry 1KY7). (D) A complex-MoRF, β-amyloid precursor protein (βAPP), bound to the PTB domain of the neuron specific protein X11 (PDB entry 1X11). Partner interfaces (gray surface) are also indicated.
Dunker et al. BMC Genomics 2008 9(Suppl 2):S1 doi:10.1186/1471-2164-9-S2-S1