Table 3

Biological interpretation about similarity between two fitness profiles

Query fitness profile

Target fitness profile

Biological interpretation of similar target treatment


Chemical-genetic (Hom)

Chemical-genetic (Hom)

Chemical effect (i.e. drug toxicity) with similar mode-of-action

Chemical-genetic (Het)

Chemical-genetic (Het)

Chemical effect with similar mode-of-action; Finding common direct drug target protein

Chemical-genetic (Hom)

Genetic-genetic (Hom)

Genetic effect (i.e. knock-out and mutations) on direct drug target protein gene

Chemical/genetic-genetic (Hom/Het)

Biological

functional annotation:

-Gene ontology

-Protein complexes

Biological functions related to chemical or genetic effect


Lee et al. BMC Genomics 2013 14(Suppl 1):S6   doi:10.1186/1471-2164-14-S1-S6

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