Figure 1.

Comparison of <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M33','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M33">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M34','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M34">View MathML</a>. An example for the comparison of performances between <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M30','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M30">View MathML</a>, where f = 1%, αstart = 1%, n = 3000, K = 100, and G = 10. The two box plots on the left are a comparison between <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M30','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M30">View MathML</a> and <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29">View MathML</a> as an estimate of f and <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M48','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M48">View MathML</a>, where <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M30','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M30">View MathML</a> shows a considerable tendency of over-estimation compared to <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29">View MathML</a>. The upper right histogram shows how <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29">View MathML</a> deviates from f in 1000 simulations, which appears to be roughly unbiasedly distributed around f. The lower right bar plot is a summary plot of the MSE for these two methods as estimates of f and ffrac, showing superiority of <a onClick="popup('http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29','MathML',630,470);return false;" target="_blank" href="http://www.biomedcentral.com/1471-2164/14/S1/S1/mathml/M29">View MathML</a> both as an estimator of f and of ffrac, in terms of MSE and Cg.

Chen and Sun BMC Genomics 2013 14(Suppl 1):S1   doi:10.1186/1471-2164-14-S1-S1