Table 2

Greater pig-human similarity revealed by gene family analysis
Family description (SF: superfamily) Number of genes found for each family per species*
Human Mouse Cow Pig
ADP-ribosyltransferase/VIP2 SF 4 5 (1) 9 4
Beta Defensin SF 39 (9) 51 (1) ~106 (7) 34 (2)
BPI SF 12 (2) 16 18 14 (2)
C-type Lysozyme/LYZ1 SF 9 9 16 7
Cathelicidin SF 1 1 10 10
CCL Chemokine 28 (1) 39 (5) 22 21
CD1 SF 5 2 15 (2) 4 (1)
CD163/WC1 SF 3 4 15 4
CLECT SF (inclusive) 85 (3) 126 (6) 89 76
CLECT SF, AGP and DCR Subfamily 16 24 (1) 14 13
CLECT SF, Collectin Subfamily 7 (2) 7 10 7
CLECT SF, NK Cell Receptor Subfamily 24 (1) 57 (5) 31 23
CLECT SF, Reg Subfamily 5 7 3 3
Cytidine Deaminase-like SF 11 (0) 5 (0) 6 (0) 5 (0)
GH18 Chitinase Like SF 6 (1) 9 (1) 8 7
Granzyme/ MC Tryptase/SP SF 17 (1) 26 (0) 22 (0) 18 (0)
Immunity Related GTP-ase SF 3 (2) 19 (4) 4 (0) 4 (0)
NLR and Pyrin SF 31 (4) 43 (8) 23 25
Resistin SF 2 4 1 2
RNase A Family 14 22 (6) 16 (1) 13 (1)
S100 SF 21 17 (1) 19 20
SAA SF 4 (1) 5 6 6
SLAM SF 9 (1) 9 (0) 12 (0) 11 (0)
Toll Like Receptor 10 (3) 12 (1) 10 10 (2)
TRIM E3 Up Ligase SF, TRIM5 Subfamily 4 10 (1) 5 3
Type I Interferon (inclusive) 17 (12) 25 (2) 51 (13) 39 (16)
Type I Interferon, Alpha Subfamily 13 (4) 13 (1) 19 (3) 18 (9)
Type I Interferon, Beta Subfamily 1 1 8 (1) 1
Type I Interferon, Delta Subfamily 0 0 0 11 (2)
Type I Interferon, Epsilon Subfamily 1 1 0 1
Type I Interferon, Kappa Subfamily 1 1 1 1
Type I Interferon, Omega Subfamily 1 (8) 0 19 (7) 7 (5)
Type I Interferon, Tau Subfamily 0 0 4 (2) 0
Type I Interferon, Zeta Subfamily 0 9 (1) 0 0
ULBP SF 6 2 12 7

* Numbers of confirmed pseudogenes are shown in parentheses. AGP and DCR: Asialo- glycoprotein and DC Receptor; MC: Mast Cell; SP: Serine Protease; Up: Ubiquitin-protein.

Dawson et al.

Dawson et al. BMC Genomics 2013 14:332   doi:10.1186/1471-2164-14-332

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