Overview of the LBFS algorithm. A statistical test was applied to get differentially expressed genes (DEGs) from the original labeled (OL) and permutated labeled (PL) samples. Subsets of 50 genes were randomly selected 1000 times from each pool of DEGs. Then literature p-values (LPvs) were calculated for each 50 gene-set. A Fisher's Exact test was used to determine if the proportion (called LCI) of subsets with LPv <0.5 in the OL group was significantly different from that obtained from PL group.
Xu et al. BMC Genomics 2012 13(Suppl 8):S23 doi:10.1186/1471-2164-13-S8-S23