Additional file 1.

This file contains (1) brief description of causal orientation algorithms; (2) results of causal orientation methods ANM, PNL, and GPI obtained by assessing statistical significance of the forward and backward causal models; (3) detailed results of significance testing of IGCI Gaussian/Entropy and Gaussian/Integral methods; (4) explanation of performance increase due to adding small amount of noise or reducing the sample size in YEAST gold standard.

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Statnikov et al. BMC Genomics 2012 13(Suppl 8):S22   doi:10.1186/1471-2164-13-S8-S22