Table 3

KEGG pathways significantly enriched in the 218 differentially expressed genes

KEGG pathway

Number of genes (%)

Nominal P-valuea

Adjusted P-valueb


Antigen processing and presentation

14 (6.42)

9.27 × 10-18

1.58 × 10-16

Lysosome

11 (5.05)

1.07 × 10-11

9.09 × 10-11

Cell adhesion molecules (CAMs)

10 (4.59)

9.31 × 10-10

5.28 × 10-9

Hematopoietic cell lineage

8 (3.67)

9.68 × 10-9

4.11 × 10-8

MAPK signaling pathway

11 (5.05)

7.17 × 10-8

2.44 × 10-7

Chemokine signaling pathway

9 (4.13)

3.31 × 10-7

8.86 × 10-7

Systemic lupus erythematosus

8 (3.67)

3.65 × 10-7

8.86 × 10-7

Intestinal immune network for IgA production

5 (2.29)

3.89 × 10-6

8.27 × 10-6

Toll-like receptor signaling pathway

6 (2.75)

8.76 × 10-6

1.65 × 10-5

T cell receptor signaling pathway

6 (2.75)

1.29 × 10-5

2.19 × 10-5

Epithelial cell signaling in Helicobacter pylori infection

5 (2.29)

1.79 × 10-5

2.77 × 10-5

Leukocyte transendothelial migration

6 (2.75)

2.13 × 10-5

3.02 × 10-5

B cell receptor signaling pathway

5 (2.29)

2.88 × 10-5

3.77 × 10-5

Ribosome

5 (2.29)

6.23 × 10-5

7.56 × 10-5

Cytokine-cytokine receptor interaction

6 (2.75)

0.0017

0.0019

Metabolic pathways

13 (5.96)

0.0023

0.0024

Pathways in cancer

6 (2.75)

0.0049

0.0049


aNominal P-value was calculated by hypergeometric test.

bAdjusted P-values was corrected of nominal P-values by Benjamini-Hochberg multiple testing correction.

Xu et al. BMC Genomics 2012 13(Suppl 8):S2   doi:10.1186/1471-2164-13-S8-S2

Open Data