This article is part of the supplement: The International Conference on Intelligent Biology and Medicine (ICIBM) – Genomics

Open Access Research

RNA-Seq analysis implicates dysregulation of the immune system in schizophrenia

Junzhe Xu123, Jingchun Sun45, Jingchun Chen6, Lily Wang7, Anna Li2, Matthew Helm2, Steven L Dubovsky1, Silviu-Alin Bacanu6, Zhongming Zhao458* and Xiangning Chen69*

Author Affiliations

1 Department of psychiatry, School of Medicine, University at Buffalo, SUNY, Buffalo, NY 14260, USA

2 VA Western New York HealthCare System, Buffalo, NY 14215, USA

3 Buffalo Psychiatric Center, Buffalo, NY 14213, USA

4 Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA

5 Department of Psychiatry, Vanderbilt University School of Medicine, Nashville, TN 37212, USA

6 Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA

7 Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA

8 Department of Cancer Biology, Vanderbilt University Medical Center, Nashville, TN 37232, USA

9 Department of Human and Molecular Genetics, Virginia Commonwealth University, Richmond, VA 23298, USA

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BMC Genomics 2012, 13(Suppl 8):S2  doi:10.1186/1471-2164-13-S8-S2

Published: 17 December 2012

Additional files

Additional file 1:

This file includes the following figures and tables. Figure S1 - Median Phred score vs. base position (cycle). Figure S2 - Distribution of the average FPKM values in the controls and cases. FPKM represents for fragments per kilobase of exon per million fragments mapped. Table S1 - Differentially expressed genes between schizophrenia patients and controls. Table S2 - Genes exclusively expressed in cases or controls. Table S3 - CAMs genes located in the MHC regions (chr6:20,000,000-40,000,000).

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