Table 6

Functional enrichment test for the 47 top ranked genes using WebGestalt.

GO ID*

Term

# genes

p-value

pBH**


GO:0007610 (BP)

Behavior

11

1.17 × 10-7

5.08 × 10-5

GO:0007214 (BP)

Gamma-aminobutyric acid signaling pathway

4

3.92 × 10-7

8.51 × 10-5

GO:0007154 (BP)

Cell communication

29

7.66 × 10-7

0.0001

GO:0007631 (BP)

Feeding behavior

5

2.16 × 10-6

0.0002

GO:0050794 (BP)

Regulation of cellular process

37

3.00 × 10-6

0.0002

GO:0050789 (BP)

Regulation of biological process

38

1.73 × 10-6

0.0002

GO:0033555 (BP)

Multicellular organismal response to stress

4

3.21 × 10-6

0.0002

GO:0007186 (BP)

G-protein coupled receptor protein signaling pathway

14

4.88 × 10-6

0.0002

GO:0007166 (BP)

Cell surface receptor linked signal transduction

19

2.53 × 10-6

0.0002

GO:0065007 (BP)

Biological regulation

38

8.70 × 10-6

0.0003

GO:0016917 (MF)

GABA receptor activity

6

3.22 × 10-11

3.35 × 10-9

GO:0004890 (MF)

GABA-A receptor activity

5

1.93 × 10-9

7.38 × 10-8

GO:0042165 (MF)

Neurotransmitter binding

7

2.13 × 10-9

7.38 × 10-8

GO:0030594 (MF)

Neurotransmitter receptor activity

6

3.56 × 10-8

9.26 × 10-7

GO:0005254 (MF)

Chloride channel activity

6

6.04 × 10-8

1.26 × 10-6

GO:0005253 (MF)

Anion channel activity

6

9.06 × 10-8

1.35 × 10-6

GO:0031404 (MF)

Chloride ion binding

6

9.06 × 10-8

1.35 × 10-6

GO:0043168 (MF)

Anion binding

6

2.64 × 10-7

3.43 × 10-6

GO:0005230 (MF)

Extracellular ligand-gated ion channel activity

5

2.22 × 10-6

2.57 × 10-5

GO:0008509 (MF)

Anion transmembrane transporter activity

6

3.99 × 10-6

4.15 × 10-5

GO:0045211 (CC)

Postsynaptic membrane

8

2.22 × 10-9

1.86 × 10-7

GO:0034707 (CC)

Chloride channel complex

6

6.57 × 10-9

2.76 × 10-7

GO:0044456 (CC)

Synapse part

9

1.20 × 10-8

3.36 × 10-7

GO:0045202 (CC)

Synapse

9

2.51 × 10-7

5.27 × 10-6

GO:0030054 (CC)

Cell junction

9

5.88 × 10-6

9.88 × 10-5

GO:0034702 (CC)

Ion channel complex

6

1.53 × 10-5

0.0002

GO:0044459 (CC)

Plasma membrane part

16

1.70 × 10-5

0.0002

GO:0031226 (CC)

Intrinsic to plasma membrane

11

0.0002

0.0019

GO:0005887 (CC)

Integral to plasma membrane

11

0.0002

0.0019

GO:0033267 (CC)

Axon part

3

0.0003

0.0025


* BP: biological process; MF: molecular function; and CC: cellular component.

** BH: p-value corrected by the Benjamini-Hochberg method (1995) [50].

Zhao et al. BMC Genomics 2012 13(Suppl 8):S16   doi:10.1186/1471-2164-13-S8-S16

Open Data