Table 3

Enriched KEGG non-metabolic pathways of the 17 key regulatory modules.

Module name

KEGG pathway

P value


FOXO3_NM

03050~Proteasome

0.0342

05213~Endometrial cancer

0.0213

05223~Non-small cell lung cancer

0.0221

TP53_NM

04110~Cell cycle

0.039

04115~p53 signaling pathway

0.0212

04210~Apoptosis

0.027

04310~Wnt signaling pathway

0.0459

04722~Neurotrophin signaling pathway

0.0384

05014~Amyotrophic lateral sclerosis (ALS)

0.0163

05210~Colorectal cancer

0.0191

05212~Pancreatic cancer

0.0215

05213~Endometrial cancer

0.016

05214~Glioma

0.02

05215~Prostate cancer

0.0273

05216~Thyroid cancer

0.009

05217~Basal cell carcinoma

0.0169

05218~Melanoma

0.0218

05219~Bladder cancer

0.013

05220~Chronic myeloid leukemia

0.0224

05222~Small cell lung cancer

0.0258

05223~Non-small cell lung cancer

0.0166

hsa_miR_16_M

04330~Notch signaling pathway

0.024

04370~VEGF signaling pathway

0.0386

04662~B cell receptor signaling pathway

0.0381

hsa_let_7e_M

04210~Apoptosis

0.0181

04722~Neurotrophin signaling pathway

0.0258

hsa_miR_30a_M

04140~Regulation of autophagy

0.0425

04144~Endocytosis

0.0264

STAT1_M

03440~Homologous recombination

0.0086

04062~Chemokine signaling pathway

0.0385

04620~Toll-like receptor signaling pathway

0.0209

04630~Jak-STAT signaling pathway

0.0317

05212~Pancreatic cancer

0.0144


One-sided Fisher's Exact Test was used to test whether the genes in a module were significantly enriched in any KEGG non-metabolic pathways. Six modules (FOXO3_NM, TP53_NM, hsa_miR_16_M, hsa_miR_30a_M, hsa_let_7e_M, STAT1_M) of which the resultant p values less than 0.05 are included in this table.

Zeng et al. BMC Genomics 2012 13(Suppl 8):S14   doi:10.1186/1471-2164-13-S8-S14

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