Table 2

Full list of 17 regulatory modules predictive of HCC metastasis.

Module name

Regulator

Targets


hsa_miR_326_M

hsa-miR-326

ARHGDIA, CEP250, MYO6, TYR, PWP2, RCBTB2, POLR3F

hsa_miR_323_3p_M

hsa-miR-323-3p

BCLAF1, SUMO1, TMBIM6, FAM168B

hsa_miR_16_M

hsa-miR-16

NFATC3, ETNK1, BMX, NCOR2, POLR3F

hsa_let_7e_M

hsa-let-7e

CLP1, NGF

FOXO3_M

FOXO3

MICAL1, SAMD8, FUBP3, ATXN10, ADAM11, RAB5C, MRPS24, DPAGT1, GPS1, SNRPC, SUMO1, TWF1, SAR1A, PICALM, TXNDC5, HEXIM2, TRIP12, ZDHHC15, SEMA4G, EFHD2

hsa_miR_22_M

hsa-miR-22

SLC6A1, SLC35A4

hsa_miR_326_NM

hsa-miR-326

MTERFD2, ARHGDIA, PCSK4, CEP250, PTRF, MYO6, ST6GALNAC6

hsa_miR_204_M

hsa-miR-204

CHD5, ATF2, POU2F2, TOMM70A, WDR26, SPOP, FAM168B, PLAA, WASF2, SRXN1

POU2F2_M

POU2F2

SPIB, C20ORF43, SUCNR1, PTRF

NFYB_M

NFYB

NTN4, CACNG5, C12ORF10, TUBA1B, CALB2, RGMA, APOC3, PGD, NDUFV1, CHDH, FBXO24, TCTN2

hsa_miR_30a_M

hsa-miR-30a

CREB1, PAWR, NEDD4, RRAS2, VPS26B, TBC1D2B, HTR4, ACAP2, ZFAND5, SPAG9, MICAL1, ATG5

hsa_miR_7_M

hsa-miR-7

PDCD2, POLR2E, NF2, FAM168B, MEGF9

CUX1_NM

CUX1

RUNX1, IFITM2, MARCH5, GPR21, RPL35, TNFRSF10B, CFP, SDHAF2, NUP62CL, YARS, NAGK, GRAMD1A, PLXNB2, BCL2L13, METTL11A, MARK3, ITM2A, HIP1R, BSG

FOXO3_NM

FOXO3

MAFF, LEPROT, MICAL1, PSME1, SAMD8, FUBP3, ATXN10

STAT1_NM

STAT1

MYBL1, MAFF, POLA1, EXOG, PGM1, ZDHHC4, WDR24, AMFR, RAD52, TMEM208, MRPL34, GCHFR, ANKRD30A, TRO, LDHAL6A, SERPING1, RNASE4, ARPC5L, SRSF3, CD248

TP53_NM

TP53

ANKRD52, SLC25A20, PGM1, C1QTNF4, PKDCC

STAT1_M

STAT1

WDR24, RAD52, GCHFR


NM indicates the existence of the module in non-metastatic HCC gene regulatory network, M indicates the existence of the module in metastatic HCC gene regulatory network.

Zeng et al. BMC Genomics 2012 13(Suppl 8):S14   doi:10.1186/1471-2164-13-S8-S14

Open Data