Comparison of global regulatory patterns between the HCC non-metastatic and metastatic networks. (A)(B). Comparison of node- and edge- distributions between the HCC metastatic and non-metastatic networks. Nodes or edges were divided into three categories: only in non-metastatic network(NM-specific), only in metastatic network(M-specific), and common in both networks. (C). Increased rate of average number of targets of a regulator in the metastatic network versus the non-metastatic. For each TF- or miRNA- relations as a whole, average number of targets was calculated in each network, and then the increased rate of the average number of targets in the metastatic network versus the non-metastatic one was represented in barplot. The color of the bar represents the type of targets, TF in green, miRNA in red, and gene in blue.
Zeng et al. BMC Genomics 2012 13(Suppl 8):S14 doi:10.1186/1471-2164-13-S8-S14