Performance assessment for the Alt Event Finder. A) The total number of identified events increases with sequencing depth. Each dot corresponds to a sample; the color and the shape of the sample denote its biological condition; the regression line is displayed in dashed line with an R-squared value of 0.9383; B) Performance for the Alt Event Finder pairing with a customized alignment pipeline and Cufflinks. The X-axis (rate of known events) is defined by the number of overlapping events divided by the number of data-driven events, and Y-axis (recall) is defined as the number of overlapping events divided by the number of events in the official MISO annotation library; C) The rate of known events does not change with sequencing depth; D) The recall rate of the Alt Event Finder increase linearly with the logarithmic transformation of the total mappable reads. The regression line is displayed in dashed line with an R-squared value of 0.9684.
Zhou et al. BMC Genomics 2012 13(Suppl 8):S10 doi:10.1186/1471-2164-13-S8-S10