Table 3

KEGG pathways inferred from predicted ES proteins

Parent KEGG pathway

No. of ESPs

Top KEGG pathway in the category


Metabolism:


Carbohydrate metabolism

296

Citrate cycle (TCA cycle)

Lipid metabolism

221

Fatty acid metabolism

Amino acid metabolism

217

Valine, leucine and isoleucine degradation

Energy metabolism

188

Oxidative phosphorylation

Glycan biosynthesis and metabolism

167

N-Glycan biosynthesis

Nucleotide metabolism

137

Purine metabolism

Xenobiotics Biodegradation and Metabolism

104

Metabolism of xenobiotics by cytochrome P450, Drug metabolism - other enzymes

Metabolism of Cofactors and Vitamins

95

Riboflavin metabolism

Metabolism of other amino acids

70

Glutathione metabolism

Biosynthesis of other Secondary Metabolites

38

Isoquinoline alkaloid biosynthesis

Metabolism of Terpenoids and Polyketides

29

Terpenoid backbone biosynthesis, Limonene and pinene degradation


Genetic Information processing:


Folding, sorting and degradation

446

Protein processing in endoplasmic reticulum

Translation

334

RNA transport

Transcription

176

Spliceosome

Replication and repair

72

Nucleotide excision repair


Environmental information processing:


Signal transduction

243

MAPK signaling pathway

Signalling, molecules and interaction

23

Cell adhesion molecules (CAMs)

Membrane transport

6

ABC transporters


Cellular processes:


Transport and catabolism:

436

Lysosome

Cell Growth and Death

208

Cell cycle

Cell communication

130

Tight junction

Cell Motility

35

Regulation of actin cytoskeleton


Organismal systems:


Immune system

291

Antigen processing and presentation

Nervous System

186

Glutamatergic synapse

Endocrine system

172

Insulin signaling pathway

Digestive System

80

Pancreatic secretion

Circulatory System

52

Cardiac muscle contraction

Excretory System

51

Proximal tubule bicarbonate reclamation

Development

47

Axon guidance

Environmental Adaptation

30

Circadian rhythm - mammal

Sensory System

15

Phototransduction


Human Diseases:


Infectious Diseases

522

HTLV-I infection

Neurodegenerative Diseases

417

Alzheimer's disease

Cancers

241

Pathways in cancer (overview)

Cardiovascular Diseases

55

Hypertrophic cardiomyopathy (HCM), Arrhythmogenic right ventricular cardiomyopathy (ARVC)

Immune Diseases

44

Rheumatoid arthritis

Endocrine and Metabolic Diseases

19

Type II diabetes mellitus


Garg and Ranganathan BMC Genomics 2012 13(Suppl 7):S8   doi:10.1186/1471-2164-13-S7-S8

Open Data