Table 4

The disease association of iLOCi selected genes from gene-only SNP analyses

Disease

# iLOCi genes in top 1000 SNP pairs

Reported in WTCCC

single SNP analyses

Reported in HuGE Navigator database


# Analyzed genes

(# SNPs)

# iLOCi genes

# Analyzed genes

(# SNPs)

# iLOCi genes


BD

654

42 (1757)

8

665 (16598)

52

CAD

710

29 (2097)

3

735 (11564)

37

CD

279

54 (1651)

4

531 (7181)

10

HT

595

32 (3164)

19

1240 (22004)

64

RA

677

34 (822)

4

503 (5902)

19

T1D

687

39 (1153)

5

512 (6924)

29

T2D

486

29 (1289)

5

2456 (41244)

110


The table displays the number of previously reported disease-associated genes which were found in all analyzed genes and in the set of genes involved in top 1000 interaction pairs. The reported disease genes are shown for both the genes associated with disease SNPs from WTCCC paper [3] and the ones reported in HuGE Navigator database [33].

Piriyapongsa et al. BMC Genomics 2012 13(Suppl 7):S2   doi:10.1186/1471-2164-13-S7-S2

Open Data