Table 7

Confirmation papers for the first new interaction predicted in 2005 for each subnetwork.

Subnetwork

Dimensional Space

First Interaction

Confirmation Papers


1

disease × drug

impotence

divalproex

[56,57]

2

disease × gene

acquired immunodeficiency syndrome

transforming growth factor, beta 1

[58,59]

3

disease × target

arrhythmia

cyclic-gmp phosphodiesterase

[60]

4

drug × gene

ciclosporin

androgen receptor

[61,62]

5

drug × target

verapamil

cyclooxygenase 2

none

6

gene × target

androgen receptor

adrenaline

[9]


7

disease × drug × gene

gout

hydrochlorothiazide

endothelin 1

none

8

disease × drug × target

alzheimer’s disease

aspirin

adrenaline

none

9

disease × gene × target

parkinson’s disease

apolipoprotein e

choline acetylase

none

10

drug × gene × target

acarbose

apolipoprotein a-1

lymphotoxin

none


11

disease × drug × gene × target

breast cancer

tamoxifen

ppar-gamma

hmg-coa reductase

none


Maciel et al. BMC Genomics 2011 12(Suppl 4):S1   doi:10.1186/1471-2164-12-S4-S1

Open Data