Table 5

The top 5 known interactions with high interaction level in 2005 that became new interactions in 2004. The interaction level of known interactions was determined by the arithmetic average of all similarities returned by the vector space model.

Subnetwork

Dimensional Space

Interaction

Level in 2005

Level in 2004

Patents in 2005

Patents in 2004


5

disease

gene

heart attack

ppar-gamma

0.9999

0.8324

1

61

1

target

disease

adrenaline

cardiac ischemia

0.9866

0.8676

1

36

11

target

disease

drug

gene

hmg coa reduct.

breast cancer

tamoxifen

kennedy disease

0.9190

0.6383

1

5

2

target

drug

gp iib/iiia

neoral

0.9137

0.8354

1

103

4

disease

drug

HIV

bonyl

0.9041

0.8825

1

30


Maciel et al. BMC Genomics 2011 12(Suppl 4):S1   doi:10.1186/1471-2164-12-S4-S1

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