Table 4

Ranking of subnetworks based on their best new interactions and number of dimensions. The interaction level of known interactions was determined by the arithmetic average of all similarities returned by the vector space model.

Subnetwork

Dimensional Space

New Interaction

Level of Interaction


6

gene

target

androgen receptor

adrenaline

0.9757

2

disease

gene

HIV

transforming growth factor, beta 1

0.9738

5

drug

target

verapamil

cyclooxygenase 2

0.9597

1

disease

drug

erectile dysfunction

divalproex

0.9470

3

disease

target

arrhythmia

cyclic-gmp phosphodiesterase

0.9272

4

drug

gene

ciclosporin

androgen receptor

0.8211


8

disease

drug

target

alzheimer dementia

acetylsalicylic acid

adrenaline

0.8807

10

drug

gene

target

acarbose

apolipoprotein a 1

lymphotoxin

0.8723

9

disease

gene

target

parkinson disease

apolipoprotein e

choline acetylase

0.8695

7

disease

drug

gene

gout

hydrochlorothiazide

endothelin 1

0.8357


11

disease

drug

gene

target

breast adenocarcinoma

tamoxifen

ppar-gamma

hmg-coa reductase

0.7826


Maciel et al. BMC Genomics 2011 12(Suppl 4):S1   doi:10.1186/1471-2164-12-S4-S1

Open Data