Table 5

Comparison of physical interactions and predicted physical interologs datasets

Organism

Benchmark dataset

Testing PPI dataset

Jaccard coefficient

Precision

Recall

Overlapping PPIs No.


M. tuberculosis H37Rv

H37Rv pull-down interologs

H37Rv physical interologs

0.021

0.205

0.023

40

M. tuberculosis H37Rv

H37Rv B2H PPI

H37Rv physical interologs

0.005

0.005

0.050

2

S. aureus MRSA252

MRSA252 Pull Down PPI dataset

MRSA252 physical interologs

0.019

0.126

0.022

23


Summary of the comparison results between physical interactions and predicted interologs datasets. “H37Rv physical interologs dataset” consists of interologs transferred from “selected IntAct prokaryotic physical interactions dataset” to M. tuberculosis H37Rv; “MRSA252 physical interologs dataset” consists of interologs transferred from “selected IntAct prokaryotic physical interactions dataset” to S. aureus MRSA252; “H37Rv pull-down interologs dataset” consists of interologs transferred from “S. aureus MRSA252 high-throughput pull-down PPI dataset” to M. tuberculosis H37Rv.

Zhou and Wong BMC Genomics 2011 12(Suppl 3):S20   doi:10.1186/1471-2164-12-S3-S20

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