Table 4

Results of predicted interologs from STRING experimental PPIs (with other STRING database prediction support)

Source PPIs for homology transfer

STRING database experimental PPIs (with other prediction support)


Identify homology and transfer

PIDE >30

HVAL >20

Orthologues

Coverage >0.2

E-value <1*e-6

Identified by inparanoid (default parameters)

E-value< 1*e-10


Benchmark

M.tuberculosis H37Rv high-throughput B2H PPIs dataset


Jaccard coefficient

0.00485

0.00225

0.00359

Precision

0.00507

0.00267

0.00401

Recall

0.100

0.0563

0.0331

Overlapping PPIs

5

4

4


Benchmark

M.tuberculosis H37Rv predicted functional associations datasetfrom STRING database (with PPIs score above 770)


Jaccard coefficient

0.365

0.233

0.186

Precision

0.467

0.314

0.365

Recall

0.625

0.473

0.275

Overlapping PPIs

651

828

524


Predicted interologs from STRING experimental PPIs (with other STRING database prediction support) and a summary of Jaccard coefficient, precision and recall between the interologs datasets and two benchmarks.

Zhou and Wong BMC Genomics 2011 12(Suppl 3):S20   doi:10.1186/1471-2164-12-S3-S20

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