Table 3

Results of predicted interologs from STRING experimental PPIs

Source PPIs for homology transfer

STRING database experimental PPIs


Identify homology and transfer

PIDE >30

HVAL >20

Orthologues

Coverage >0.2

E-VALUE <1*e-6

Identified by Inparanoid (default parameters)

E-VALUE< 1*e-10


Benchmark

M.tuberculosis H37Rv high-throughput B2H PPIs dataset


Jaccard coefficient

0.00354

0.00187

0.00289

Precision

0.00375

0.00196

0.00339

Recall

0.0588

0.0384

0.0190

Overlapping PPIs

5

4

5


Benchmark

M.tuberculosis H37Rv predicted functional associations dataset from STRING database(with PPIs score above 770)


Jaccard coefficient

0.285

0.179

0.129

Precision

0.355

0.236

0.239

Recall

0.625

0.422

0.219

Overlapping PPIs

656

830

525


Predicted interologs from STRING experimental PPIs and a summary of Jaccard coefficient, precision and recall between the interologs datasets and two benchmarks.

Zhou and Wong BMC Genomics 2011 12(Suppl 3):S20   doi:10.1186/1471-2164-12-S3-S20

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