Table 4 |
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|
Prediction of granzyme B cleavage of CHIKV proteome |
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|
Protein |
Biological activity and function |
Cleavage sites* |
|
|
||
|
NSP1 |
Non-structural: mRNA capping |
9, 11, 58, 525 |
|
NSP2 |
Non-structural: NTPase, helicase and protease activities |
116, 247, 343 |
|
NSP3 |
Non-structural: ADP-ribose phosphatase activity |
181, 350, 363, 506 |
|
NSP4 |
Non-structural: RNA polymerase activity |
219, 371, 476, 540 |
|
E1 |
Structural: virus-host cell fusion |
Nil |
|
E2 |
Structural: virus-host cell attachment |
77 |
|
E3 |
Structural: unknown |
Nil |
|
Capsid |
Structural: protease, viral nucleocapsid formation |
112, 174 |
|
6K |
Structural: membrane permeabilization, budding of viral particles |
Nil |
|
|
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|
*Position of the P1 residue on the substrate. All predicted cleavage sites contain Asp at P1. Underlines indicate P1 location in the functional domain(s) of protein. |
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|
Wee et al. BMC Genomics 2011 12(Suppl 3):S11 doi:10.1186/1471-2164-12-S3-S11 |
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