Table 4

Prediction of granzyme B cleavage of CHIKV proteome

Protein

Biological activity and function

Cleavage sites*


NSP1

Non-structural: mRNA capping

    9
,
    11
,
    58
, 525

NSP2

Non-structural: NTPase, helicase and protease activities

116,

    247
,
    343

NSP3

Non-structural: ADP-ribose phosphatase activity

181, 350, 363, 506

NSP4

Non-structural: RNA polymerase activity

    219
,
    371
,
    476
,
    540

E1

Structural: virus-host cell fusion

Nil

E2

Structural: virus-host cell attachment

77

E3

Structural: unknown

Nil

Capsid

Structural: protease, viral nucleocapsid formation

    112
,
    174

6K

Structural: membrane permeabilization, budding of viral particles

Nil


*Position of the P1 residue on the substrate. All predicted cleavage sites contain Asp at P1. Underlines indicate P1 location in the functional domain(s) of protein.

Wee et al. BMC Genomics 2011 12(Suppl 3):S11   doi:10.1186/1471-2164-12-S3-S11

Open Data