Web interface of PDbase. PDbase provides user-friendly web interfaces. When a user selects the 'SPP1' gene from the category search page, search results (a) containing as follows: (1) "EST statistics" part: number of SN ESTs from normal and PD patients, number of SN ESTs associated with repeat elements and alternative splicing events, and probability of differential gene expression with SN ESTs. (2) "Gene Information" part: gene-related information about gene symbol and synonymous, description, HGNC, OMIM, Ensemble Gene, and HPRD. When click each link, user can get more detailed information. (3) "Genomic variation" part: detailed information about alternative splicing events, repeat elements, and SNPs in gene region annotated from SN ESTs. (4) "Gene Regulation" part: micro RNA elements to regulate the query gene (SPP1). (5) "Gene Ontology" part: gene distribution in three gene ontology categories. GO ids, terms, and evidence are based on the Gene Ontology database. (6) "Network" part: the query gene-related protein-protein interaction and biological pathways, such as BioCarta and KEGG. When the user clicks on the PPI viewer in a search result page, interactive java applet viewer (b) shows the interaction network containing the selected protein and its interacting partners.
Yang et al. BMC Genomics 2009 10(Suppl 3):S32 doi:10.1186/1471-2164-10-S3-S32