Degradation and down-regulation pathways containing alternative paths to HIV-1 targeted paths. A. Ubiquitin dependent degradation of cyclin D1. The colored circle represents the proteasome complex. B. Vif-mediated degradation of Apobec3g. The same proteasome complex shown in A is part of this pathway also. This is an HIV-1 specific pathway as per its listing in the pathway database, and thus already contains HIV-1 proteins as part of the pathway. C. EGFR down-regulation. Here, down-regulation is achieved via internalization. The color coding is as follows: Purple - HIV target (according to G1, except in the cholesterol one where the purple is according to predictions). Blue - si-RNA, Red - Drug Target, Yellow - All 3, Green - si-RNA and Drug, Target, Silver - Drug Target and Group 1, Brown - siRNA and Group 1.
Balakrishnan et al. BMC Genomics 2009 10(Suppl 3):S30 doi:10.1186/1471-2164-10-S3-S30