Example annotated tree (Arctree) produced by MINER. Screenshot from the MINER GUI showing a decision tree of genes whose expression in the input microarray data set can predict the expression of the target gene YDR468C. For example, in this case, the tree indicates that YDR468C was down-regulated in the data set when the expression of YGL214W had a normalised expression level of 0 or less and YGR196C had a normalised expression level of 0.04 or less. Placing the mouse over a node of the tree displays coloured arcs representing the "annotation distance" between the gene represented by this node and other genes in the tree. Genes who share more GO annotations are linked by thicker arcs. The colour of the arc corresponds to the GO category represented (Biological Process, Molecular Function, Cellular Component). For example, in this case, YGR196C and YER101C share similar GO function, process and localisation annotations. Depending on the radio button setting, clicking on a node either displays external annotations on the corresponding gene or launches a new tree learning analysis using the corresponding gene as the new target.
Kadupitige et al. BMC Genomics 2009 10(Suppl 3):S17 doi:10.1186/1471-2164-10-S3-S17