The modern understanding of the fate of a polypeptide chain inside a cell. Three types of IDPs, native coil, native pre-molten globule, and native molten globule are schematically shown together with the structure of an ordered protein and an amyloid fibril. Here, newly synthesized polypeptide chain can either undergo specific folding to gain a unique structure necessary for the catalytic and transport activities, or stay substantially non-folded or misfold and form amyloid-like fibrils. Both folded and non-folded proteins have specific biological functions.
Uversky et al. BMC Genomics 2009 10(Suppl 1):S7 doi:10.1186/1471-2164-10-S1-S7