Table 3

Lowest level GO terms that differed in QTL regions compared to the genome as a whole.

GO Term

Description

Population Frequency

QTL/Population

p-value


Body Conformation

GO:0005254

chloride channel activity

0.00115

8.29

2.89E-04

GO:0030594

neurotransmitter receptor activity

0.00159

8.39

1.61E-05

GO:0048500

signal recognition particle

0.00040

14.38

9.38E-04

GO:0004890

GABA-A receptor activity

0.00102

11.25

1.09E-05

GO:0005230

extracellular ligand-gated ion channel activity

0.00159

9.58

1.35E-06

GO:0007214

gamma-aminobutyric acid signaling pathway

0.00111

8.63

2.38E-04

GO:0045202

synapse

0.00766

2.99

7.42E-04

GO:0045211

postsynaptic membrane

0.00394

4.36

2.22E-04

Carcass

GO:0050806

positive regulation of synaptic transmission

0.00031

3.38

2.00E-04

GO:0016600

flotillin complex

0.00031

3.38

2.00E-04

GO:0051059

NF-kappaB binding

0.00088

2.36

2.24E-04

GO:0006986

response to unfolded protein

0.00208

1.87

2.07E-04

Disease Resistance

GO:0046785

microtubule polymerization

0.00035

15.50

5.33E-06

GO:0031116

positive regulation of microtubule polymerization

0.00035

15.50

5.33E-06

GO:0009925

basal plasma membrane

0.00049

13.53

1.64E-06

GO:0001937

negative regulation of endothelial cell proliferation

0.00044

12.40

2.24E-05

GO:0007154

cell communication

0.00389

3.38

2.10E-04

GO:0042493

response to drug

0.00195

4.51

3.30E-04

GO:0004620

phospholipase activity

0.00022

19.85

1.27E-05

GO:0019900

kinase binding

0.00058

9.54

1.03E-04

GO:0042470

melanosome

0.00049

9.02

6.90E-04

GO:0043434

response to peptide hormone stimulus

0.00084

6.53

7.63E-04

GO:0030659

cytoplasmic vesicle membrane

0.00035

12.40

1.61E-04

GO:0016599

caveola

0.00053

10.34

6.58E-05

GO:0019905

syntaxin binding

0.00058

9.54

1.03E-04

GO:0009395

phospholipid catabolic process

0.00031

14.18

8.33E-05

GO:0050998

nitric-oxide synthase binding

0.00035

15.50

5.33E-06

GO:0030321

transepithelial chloride transport

0.00031

14.18

8.33E-05

GO:0042311

vasodilation

0.00040

11.03

2.81E-04

GO:0019861

flagellum

0.00111

5.95

3.87E-04

GO:0007595

lactation

0.00084

6.53

7.63E-04

GO:0030317

sperm motility

0.00084

7.83

7.29E-05

Fat

GO:0051059

NF-kappaB binding

0.00088

2.33

1.06E-04

GO:0006986

response to unfolded protein

0.00208

1.85

1.01E-04

Growth

GO:0007586

digestion

0.00133

2.79

2.66E-04

Milk Protein

GO:0050785

advanced glycation end-product receptor activity

0.00027

4.67

9.67E-05

GO:0051059

NF-kappaB binding

0.00088

3.27

4.36E-06

GO:0006986

response to unfolded protein

0.00208

2.28

2.71E-05

GO:0007584

response to nutrient

0.00217

2.19

6.25E-05

Milk Yield

GO:0005922

connexon complex

0.00080

3.31

2.05E-04

GO:0030375

thyroid hormone receptor coactivator activity

0.00040

4.64

9.74E-05

GO:0042809

vitamin D receptor binding

0.00071

3.35

3.82E-04

GO:0042974

retinoic acid receptor binding

0.00031

5.96

3.71E-06

GO:0004886

retinoid-X receptor activity

0.00044

4.77

2.03E-05

Reproduction

GO:0005882

intermediate filament

0.00186

3.16

1.38E-06


The table describes fine detail GO terms found to be significantly over represented through hypergeometric analysis. In bold are the QTL categories from which the subsequent terms were found to be in abundance. Population frequency describes the frequency of the occurrence of the GO code genome wide. QTL/Population describes the ratio of the frequency of a GO code within a QTL region compared to the frequency of that GO code genome wide.

Salih and Adelson BMC Genomics 2009 10:184   doi:10.1186/1471-2164-10-184

Open Data