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Bovine: the companion papers for the publication of the bovine genome sequence

The cow (Bos taurus) is an important model organism for biomedical research and development, in addition to being agriculturally important. This special series of companion papers includes work from both the Bovine Genome Sequencing and Analysis Consortium and the Bovine HapMap Consortium.

  1. Content type: Research article

    Copy number variation (CNV) represents another important source of genetic variation complementary to single nucleotide polymorphism (SNP). High-density SNP array data have been routinely used to detect human ...

    Authors: Yali Hou, George E Liu, Derek M Bickhart, Maria Francesca Cardone, Kai Wang, Eui-soo Kim, Lakshmi K Matukumalli, Mario Ventura, Jiuzhou Song, Paul M VanRaden, Tad S Sonstegard and Curt P Van Tassell

    Citation: BMC Genomics 2011 12:127

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  2. Content type: Research

    The majority of the 2 million bovine single nucleotide polymorphisms (SNPs) currently available in dbSNP have been identified in a single breed, Hereford cattle, during the bovine genome project. In an attempt...

    Authors: Sebastian H Eck, Anna Benet-Pagès, Krzysztof Flisikowski, Thomas Meitinger, Ruedi Fries and Tim M Strom

    Citation: Genome Biology 2009 10:R82

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  3. Content type: Research article

    Neuropeptides are cell to cell signalling molecules that regulate many critical biological processes including development, growth and reproduction. These peptides result from the complex processing of prohorm...

    Authors: Bruce R Southey, Sandra L Rodriguez-Zas and Jonathan V Sweedler

    Citation: BMC Genomics 2009 10:228

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  4. Content type: Research article

    The assortment of cattle immunoglobulin and surrogate light chain genes has been extracted from the version 3.1 of Bos taurus genome sequence as a part of an international effort to sequence and annotate the bovi...

    Authors: Anna Ekman, Mikael Niku, Jenni Liljavirta and Antti Iivanainen

    Citation: BMC Immunology 2009 10:22

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  5. Content type: Research article

    WC1 co-receptors are group B scavenger receptor cysteine-rich molecules that are found exclusively on γδT cells and are thought to be encoded by a multi-gene family. Previous studies have shown γδT cells that ...

    Authors: Carolyn TA Herzig and Cynthia L Baldwin

    Citation: BMC Genomics 2009 10:191

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  6. Content type: Research article

    Recent technological advances have made it possible to efficiently genotype large numbers of single nucleotide polymorphisms (SNPs) in livestock species, allowing the production of high-density linkage maps. S...

    Authors: Juan A Arias, Mike Keehan, Paul Fisher, Wouter Coppieters and Richard Spelman

    Citation: BMC Genetics 2009 10:18

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  7. Content type: Research article

    The Pregnancy-associated glycoproteins (PAGs) belong to a large family of aspartic peptidases expressed exclusively in the placenta of species in the Artiodactyla order. In cattle, the PAG gene family is comprise...

    Authors: Bhanu Prakash VL Telugu, Angela M Walker and Jonathan A Green

    Citation: BMC Genomics 2009 10:185

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  8. Content type: Research article

    Embryonic genome activation (EGA) is a critical event for the preimplantation embryo, which is manifested by changes in chromatin structure, transcriptional machinery, expression of embryonic genes, and degrad...

    Authors: Alper Uzun, Nelida Rodriguez-Osorio, Abdullah Kaya, Hongfeng Wang, John J Parrish, Valentin A Ilyin and Erdogan Memili

    Citation: BMC Genomics 2009 10:183

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  9. Content type: Research article

    If mutation within the coding region of the genome is largely not adaptive, the ratio of nonsynonymous (dN) to synonymous substitutions (dS) per site (dN/dS) should be approximately equal among closely related...

    Authors: Sean MacEachern, John McEwan, Alan McCulloch, Andrew Mather, Keith Savin and Mike Goddard

    Citation: BMC Genomics 2009 10:179

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  10. Content type: Research article

    Identifying recent positive selection signatures in domesticated animals could provide information on genome response to strong directional selection from domestication and artificial selection. With the compl...

    Authors: Sean MacEachern, Ben Hayes, John McEwan and Mike Goddard

    Citation: BMC Genomics 2009 10:181

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  11. Content type: Research article

    The Bovinae subfamily incorporates an array of antelope, buffalo and cattle species. All of the members of this subfamily have diverged recently. Not surprisingly, a number of phylogenetic studies from molecul...

    Authors: Sean MacEachern, John McEwan and Mike Goddard

    Citation: BMC Genomics 2009 10:177

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  12. Content type: Research article

    Genome comparisons have made possible the reconstruction of the eutherian ancestral karyotype but also have the potential to provide new insights into the evolutionary inter-relationship of the different euthe...

    Authors: Claus Kemkemer, Matthias Kohn, David N Cooper, Lutz Froenicke, Josef Högel, Horst Hameister and Hildegard Kehrer-Sawatzki

    Citation: BMC Evolutionary Biology 2009 9:84

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  13. Content type: Research article

    Detailed information regarding the number and organization of transfer RNA (tRNA) genes at the genome level is becoming readily available with the increase of DNA sequencing of whole genomes. However the ident...

    Authors: Dave TP Tang, Evgeny A Glazov, Sean M McWilliam, Wesley C Barris and Brian P Dalrymple

    Citation: BMC Genomics 2009 10:188

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  14. Content type: Research article

    The Bovine HapMap Consortium has generated assay panels to genotype ~30,000 single nucleotide polymorphisms (SNPs) from 501 animals sampled from 19 worldwide taurine and indicine breeds, plus two outgroup spec...

    Authors: Rafael Villa-Angulo, Lakshmi K Matukumalli, Clare A Gill, Jungwoo Choi, Curtis P Van Tassell and John J Grefenstette

    Citation: BMC Genetics 2009 10:19

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  15. Content type: Research article

    Successful reprogramming of a somatic genome to produce a healthy clone by somatic cells nuclear transfer (SCNT) is a rare event and the mechanisms involved in this process are poorly defined. When serial or s...

    Authors: Nelida Rodriguez-Osorio, Zhongde Wang, Poothappillai Kasinathan, Grier P Page, James M Robl and Erdogan Memili

    Citation: BMC Genomics 2009 10:190

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  16. Content type: Research article

    Linkage analyses strongly suggest a number of QTL for production, health and conformation traits in the middle part of bovine chromosome 6 (BTA6). The identification of the molecular background underlying the ...

    Authors: Rosemarie Weikard, Tom Goldammer, Annett Eberlein and Christa Kuehn

    Citation: BMC Genomics 2009 10:186

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  17. Content type: Research article

    The goal of genome wide analyses of polymorphisms is to achieve a better understanding of the link between genotype and phenotype. Part of that goal is to understand the selective forces that have operated on ...

    Authors: William Barendse, Blair E Harrison, Rowan J Bunch, Merle B Thomas and Lex B Turner

    Citation: BMC Genomics 2009 10:178

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  18. Content type: Research article

    We present here the assembly of the bovine genome. The assembly method combines the BAC plus WGS local assembly used for the rat and sea urchin with the whole genome shotgun (WGS) only assembly used for many o...

    Authors: Yue Liu, Xiang Qin, Xing-Zhi Henry Song, Huaiyang Jiang, Yufeng Shen, K James Durbin, Sigbjørn Lien, Matthew Peter Kent, Marte Sodeland, Yanru Ren, Lan Zhang, Erica Sodergren, Paul Havlak, Kim C Worley, George M Weinstock and Richard A Gibbs

    Citation: BMC Genomics 2009 10:180

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  19. Content type: Research article

    Fertility is one of the most critical factors controlling biological and financial performance of animal production systems and genetic improvement of lines. The objective of this study was to identify molecul...

    Authors: Jean M Feugang, Abdullah Kaya, Grier P Page, Lang Chen, Tapan Mehta, Kashif Hirani, Lynne Nazareth, Einko Topper, Richard Gibbs and Erdogan Memili

    Citation: BMC Genomics 2009 10:176

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  20. Content type: Research

    The newly assembled Bos taurus genome sequence enables the linkage of bovine milk and lactation data with other mammalian genomes.

    Authors: Danielle G Lemay, David J Lynn, William F Martin, Margaret C Neville, Theresa M Casey, Gonzalo Rincon, Evgenia V Kriventseva, Wesley C Barris, Angie S Hinrichs, Adrian J Molenaar, Katherine S Pollard, Nauman J Maqbool, Kuljeet Singh, Regan Murney, Evgeny M Zdobnov, Ross L Tellam…

    Citation: Genome Biology 2009 10:R43

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  21. Content type: Research article

    Bidirectional promoters are shared regulatory regions that influence the expression of two oppositely oriented genes. This type of regulatory architecture is found more frequently than expected by chance in th...

    Authors: Helen Piontkivska, Mary Q Yang, Denis M Larkin, Harris A Lewin, James Reecy and Laura Elnitski

    Citation: BMC Genomics 2009 10:189

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  22. Content type: Research article

    The cattle MHC is termed the bovine leukocyte antigen (BoLA) and, along with the MHCs of other ruminants, is unique in its genomic organization. Consequently, correct and reliable gene maps and sequence inform...

    Authors: Candice L Brinkmeyer-Langford, Christopher P Childers, Krista L Fritz, Ashley L Gustafson-Seabury, Marian Cothran, Terje Raudsepp, James E Womack and Loren C Skow

    Citation: BMC Genomics 2009 10:182

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  23. Content type: Commentary

    The draft genome sequence of cattle (Bos taurus) has now been analyzed by the Bovine Genome Sequencing and Analysis Consortium and the Bovine HapMap Consortium, which together represent an extensive collaboration...

    Authors: Ross L Tellam, Danielle G Lemay, Curtis P Van Tassell, Harris A Lewin, Kim C Worley and Christine G Elsik

    Citation: BMC Genomics 2009 10:193

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