Figure 12.

Example for the dynamics of a simple FSLM network. A In this negative feedback loop the substance generator produces a substance, which acts as a repressor of its own control function. B Environment change graph recording the changes in repressor concentration during time. From the initial concentration the repressor accumulates with rate r+ until the association constant of the binding site brep is reached at time t1. Then the substance generator is switched off and the repressor degrades with rate r- until the dissociation constant is reached at time t2. The substance generator then produces the repressor until the association constant is reached again (means Boolean „not“). Reproduced from [2].

Schlitt and Brazma BMC Bioinformatics 2007 8(Suppl 6):S9   doi:10.1186/1471-2105-8-S6-S9