BMC Bioinformatics

official impact factor 3.03

This article is part of the supplement: APBioNet – Fifth International Conference on Bioinformatics (InCoB2006)

Open Access Proceedings

Fly-DPI: database of protein interactomes for D. melanogaster in the approach of systems biology

Chung-Yen Lin1,2,3*, Shu-Hwa Chen4, Chi-Shiang Cho1, Chia-Ling Chen1, Fan-Kai Lin1, Chieh-Hua Lin1, Pao-Yang Chen1, Chen-Zen Lo1 and Chao A Hsiung1*

Author Affiliations

1 Division of Biostatistics and Bioinformatics, National Health Research Institutes. No. 35 Keyan Rd. Zhunan, Miaoli County 350, Taiwan

2 Institute of Information Science, Academia Sinica, No. 128 Yan-Chiu-Yuan Rd., Sec. 2, Taipei 115, Taiwan

3 Institute of Fishery Science, National Taiwan University, No. 1, Sec 4, Roosevelt Road, Taipei, 10617, Taiwan

4 Stem Cell/Regenerative Medicine Program, Genomics Research Center, Academia Sinica., No. 128 Yan-Chiu-Yuan Rd., Sec. 2, Taipei 115, Taiwan

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BMC Bioinformatics 2006, 7(Suppl 5):S18 doi:10.1186/1471-2105-7-S5-S18

Published: 18 December 2006

Additional files

Additional File 1:

To apply Jack-knife method in the validation, in each time test set is re-sampled and the average sensitivity and specificity are calculated. The ratio between the size of the training set and test set is set to be 9:1.

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Additional File 3:

Comparison with all dataset existed in BIND with Fly-DPI (all).

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Additional File 4:

Comparison with all dataset existed in BIND with Fly-DPI (high confidence).

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Additional File 2:

Distribution of the shortest path between pairs of proteins in Fly-DPI. On average, any two proteins in the network are connected via 3.78 (all interactions) and 4.06 (interactions with high confidence) in our data, respectively.

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