Flow chart of StudentB. StudentB first logarithmizes the E-Values of all BLAST hits and averages them. The result is mapped into a range from 0 to 1 by looking up its percentile in a precompiled distribution. This percentile is the Template Quality Score and reflects how well we can predict the entire target. To score single terms, we multiply it with the score of each predicted leaf, i.e. the Combined Leaf Score. This is the average of the logarithmized E-Values of the nodes on the path from the leaf to the root. The propagation of the leaf terms and their scores is output to the user.
Hamp et al. BMC Bioinformatics 2013 14(Suppl 3):S7 doi:10.1186/1471-2105-14-S3-S7