Table 5

The top 5 false positive predictions made by GOstruct.

Protein

GOstruct Prediction/Current Annotation (if dierent)

Best Supporting Sentence

Pubmed ID

GO term(s) in Supporting Sentence

Evidence Code


MGI:103293

GO:0016787 hydrolase activity

We recently demonstrated that human protein tyrosine phosphatase (PTP) L1, a large cytoplasmic phosphatase also known as PTP-BAS/PTPN13/PTP-1E, is a negative

regulator of IGF-1R/IRS-1/Akt path-way in breast cancer cells.

19782949

GO:0004722

IEA

MGI:103305

GO:0016787 hydrolase activity/N/A

N/A

N/A

N/A

N/A

MGI:104597

GO:0016740 transferase activity/N/A

Using this assay system, chloramphenicol acetyltransferase activity directed by the cTNT promoter/upstream region was between two and three orders of magnitude higher in cardiac or skeletal muscle cells than in fibroblast cells, indicating that cis elements responsible for cell-specific expression reside in this region of the cTNT gene. Many Andersen syndrome cases have been associated with loss-of-function mutations in the inward rectifier K(+) channel Kir2.1 encoded by KCNJ2.

3047142

GO:0008811

GO:0016407

N/A

MGI:104744

GO:0022857 transmembrane transporter activity/GO:0005242 inward rectifier

potassium

channel activity

18690034

GO:0015267

IEA

MGI:104744

GO:0022892 substrate-specific transporter activity/GO:0005242 inward rectifier potassium

channel activity

IRK1, but not GIRK1/GIRK4 channels, showed a marked specificity toward phosphates in the 4,5 head group positions.

10593888

GO:0015267

IEA


We present the best supporting sentence for the function of each protein, the document source, and the most recent known annotation along with the associated evidence code.

Sokolov et al. BMC Bioinformatics 2013 14(Suppl 3):S10   doi:10.1186/1471-2105-14-S3-S10

Open Data