Additional file 1.
Example of the GATA-1 binding sites predicted in each extant and ancestral sequences in the first exon of the NPL gene. A region bound by GATA-1, identified by ChIP-Seq, is located just upstream of the second (alternative) exon. Rows corresponding to ancestral sequences are identified by listing the names of the extant descendants of each ancestor. Panel B is a zoom on the high-scoring binding locus region. Note that the region does not exhibit elevated sequence conservation, and contains many examples of TFBS turnover.
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Blanchette BMC Bioinformatics 2012 13(Suppl 19):S2 doi:10.1186/1471-2105-13-S19-S2