Losses in the context of multiple genomes. (a) is a connected component of the similarity graph (see Section Experiments on real datasets for a description of the data) consistent with the gene history depicted in (b) representing protocadherin gamma b1 (1) and b2 (2) genes. The protocadherin gamma b1 gene is known to have been lost in rat . It is essential that human or chimp be considered in the analysis with mouse and rat, otherwise a false inparalog relationship would be inferred between the two mouse genes.
Tremblay-Savard and Swenson BMC Bioinformatics 2012 13(Suppl 19):S16 doi:10.1186/1471-2105-13-S19-S16