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This article is part of the supplement: Eleventh International Conference on Bioinformatics (InCoB2012): Bioinformatics

Open Access Proceedings

Mathematical modeling of the immune system recognition to mammary carcinoma antigen

Carlo Bianca1, Ferdinando Chiacchio2, Francesco Pappalardo3 and Marzio Pennisi4*

Author Affiliations

1 Dipartimento di Scienze Matematiche, Politecnico di Torino, Torino, Italy

2 Dipartimento di Ingegneria Informatica e delle Telecomunicazioni, Università di Catania, Catania, Italy

3 Dipartimento di Scienze del Farmaco, Università di Catania, Catania, Italy

4 Dipartimento di Matematica e Informatica, Università di Catania, Catania, Italy

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BMC Bioinformatics 2012, 13(Suppl 17):S21  doi:10.1186/1471-2105-13-S17-S21

Published: 13 December 2012

Abstract

The definition of artificial immunity, realized through vaccinations, is nowadays a practice widely developed in order to eliminate cancer disease. The present paper deals with an improved version of a mathematical model recently analyzed and related to the competition between immune system cells and mammary carcinoma cells under the action of a vaccine (Triplex). The model describes in detail both the humoral and cellular response of the immune system to the tumor associate antigen and the recognition process between B cells, T cells and antigen presenting cells. The control of the tumor cells growth occurs through the definition of different vaccine protocols. The performed numerical simulations of the model are in agreement with in vivo experiments on transgenic mice.