Figure 1.

Pfam domain content of drug targets. (a) Shows the proportion of proteins having zero, one or more domains for all human targets in the ChEMBL target dictionary (blue), protein targets of all species in the ChEMBL target dictionary (green) and all protein coding genes (orange). (b) Barplots summarizing observed ratios of residues within a Pfam domain over the number of residues in the entire protein sequence for all human targets in the ChEMBL target dictionary (blue), protein targets of all species in the ChEMBL target dictionary (green) and all protein coding genes (orange). The median ratio for all protein coding genes is 0.50 and significantly lower than the corresponding ratio for targets in the ChEMBL data base (p < 2.2*10-16, Bonferroni adjusted for multiple testing).

Kruger et al. BMC Bioinformatics 2012 13(Suppl 17):S11   doi:10.1186/1471-2105-13-S17-S11