Table 2

Predicted Recurrent Breakpoints in 227 GBM Samples and 107 Blood Samples.

Breakpoint Type

Rearrangement Type(s)

# Predicted

# in DGV

# in Blood

# Novel


Recurrent Probes in Tumor

Highly Conserved Breakpoints

538

343

13

189


Recurrent Genes in Tumor

Gene Truncations

92

69

23

23


Pairs of Recurrent Probe in Blood*

Germline Structural Variants

88

53

N/A

35


Pairs of Recurrent Genes in Tumor w/Fusion Gene Config. **

Intrachromosomal Fusion Genes

75

45

5

7

Interchromosomal Fusion Genes

396

316

53

26


Columns are described in Table 1, except for '# in Blood' which indicates the number of predictions that also appear in the blood samples and are ignored as somatic predictions.

* FDR is increased to < 0.1 for blood samples.

** Novel pairs of recurrent gene breakpoints consistent with the fusion gene configuration.

Ritz et al. BMC Bioinformatics 2011 12:114   doi:10.1186/1471-2105-12-114

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