Fusion Gene Configurations. Fusion genes are pairs of recurrent genes that have the following configuration. (A) Each gene G1 and G2 has an associated orientation, orient(G1) and orient(G2). Additionally, each recurrent breakpoint has an associated change in relative copy number, dir(G1) and dir(G2). (B) A fusion gene joins the ends of G1 and G2 such that the 5' end of one gene is joined to the 3' end of the other gene.
Ritz et al. BMC Bioinformatics 2011 12:114 doi:10.1186/1471-2105-12-114