The Neighborhood Breakpoint Conservation (NBC) algorithm. NBC consists of two steps: computing breakpoint probabilities and recurrent breakpoint detection. Copy number ratios (CNRs) derived from aCGH data from multiple individuals are segmented using a Bayesian change-point algorithm that computes the probability of a breakpoint between adjacent probes (in red). The breakpoint probabilities are then combined to detect recurrent breakpoints (black rectangles). We identify recurrent breakpoints that occur between adjacent probes as well as recurrent breakpoints that occur within a set of probes defined by a genomic interval. To detect CNVs, we identify pairs of recurrent breakpoints.
Ritz et al. BMC Bioinformatics 2011 12:114 doi:10.1186/1471-2105-12-114