Resolution:
## Figure 1.
The Neighborhood Breakpoint Conservation (NBC) algorithm. NBC consists of two steps: computing breakpoint probabilities and recurrent breakpoint
detection. Copy number ratios (CNRs) derived from aCGH data from multiple individuals
are segmented using a Bayesian change-point algorithm that computes the probability
of a breakpoint between adjacent probes (in red). The breakpoint probabilities are
then combined to detect recurrent breakpoints (black rectangles). We identify recurrent
breakpoints that occur between adjacent probes as well as recurrent breakpoints that
occur within a set of probes defined by a genomic interval. To detect CNVs, we identify
pairs of recurrent breakpoints.
Ritz |