Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • Image attributed to: Figure from Benson and colleagues colleagues
    Mikael Benson and colleagues explain how and why systems medicine, and specifically network approaches, can be used to assist clinical decision making and identify underlying disease mechanisms
  • Image attributed to: From Fig 2 from Zhao and colleagues
    A computational approach to investigate 1.2 million somatic mutations in 36 cancer types using 3D protein structure information to identify putative cancer drivers and drug response biomarkers.
  • Image attributed to: From Fig 1 from Geschwind and colleagues
    Co-expression network analysis using transcriptome data from iPSC-derived cortical neural progenitors and neurons identifies several modules and pathways specifically related to TS mutation status.
  • FunSeq2 annotates and prioritizes noncoding driver mutations from somatic alterations by incorporating large-scale genomics and cancer resources
  • A new resource offering a range of pathway data and visualization, including disease pathways and related pathway suites.

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013