Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • Image attributed to: Alberto Romeo, CC3.0

    A tangled web of algal genes

    Proteins involved in chlorophyll synthesis in algae have evolved through a tangled relationship among major lineages involving loss, duplication, and horizontal transfer of genes, demonstrating the impact these processes have had on eukaryote evolution.

    BMC Evolutionary Biology 2015, 15:16
  • Image attributed to: From Fig 2 Valencia and colleagues

    CLL and gene expression variability

    A relationship between disease subtype in chronic lymphocytic leukemia and variation in gene expression suggests that variability has an effect on tumor adaptability and aggressiveness.

    Genome Medicine 2015, 7:8
  • Image attributed to: istock

    Healthy screening: caution needed

    The Hundred Person Wellness Project aims to screen healthy individuals to avoid symptomatic disease; Eleftherios Diamandis argues that such testing could lead to over-diagnosis and over-treatment, and should be used with caution.

    BMC Medicine 2015, 13:5
  • Image attributed to: istock

    Screening to optimize wellness

    Lee Hood and colleagues discuss the benefits of the Hundred Person Wellness Project, a study that aims to monitor 100 ‘well’ individuals, arguing that the results will enable earlier disease intervention to optimize wellness and minimize illness.

    BMC Medicine 2015, 13:4
  • Image attributed to: iStock photos

    Molecular tools for DFIs

    Current methods to identify pathogens causing diabetic foot infections (DFIs) are inadequate, so Anne Spichler and colleagues suggest that developing new molecular techniques to better understand DFI microbiology will lead to better management of this complex disease.

    BMC Medicine 2015, 13:2

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013