Systems Biology Gateway

Identifying gaps in breast cancer research

Current knowledge 'gaps' in the understanding of breast cancer are examined, and research should focus on these to improve future clinical care.

Big science in biology and medicine

Leroy Hood and Lee Rowen discuss the role the Human Genome Project played in transforming biology through an integrated big science approach, and the implications for the practice of medicine.

Single-cell analysis: toward the clinic

Editorial for the single-cell series exploring how single-cell diagnostics will be instrumental for the realization of personalized medicine and for the development of novel therapeutic concepts.

RBPome recognition elements

RNA-binding proteins: Stefanie Gerstberger, Markus Hafner and Thomas Tuschl on the language of post-transcriptional gene regulation

Funding personalized medicine

Brian Godman and colleagues review the challenges and concerns associated with personalized medicine, emphasizing that it has the potential to revolutionize care, but knowledge from a payer’s perspective must be integrated to move forwards.