Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • Image attributed to: Part of fg1 form article

    Epigenetics of disease-discordant twins

    Tim Spector and colleagues review recent epigenetic studies of monozygotic twins with discordance for a variety of diseases including cancer, autoimmune disorders and neurological diseases.

    Genome Medicine 2014, 6:60
  • Image attributed to: Figure from DawnRank by Ma

    Finding personalized cancer drivers

    It is a challenge to assess whether rare and patient-specific mutations are cancer drivers. The algorithm DawnRank prioritizes altered genes on a single patient level.

    Genome Medicine 2014, 6:56
  • Image attributed to: Detail of Figure 5 from Jeong et al.

    Systematic cancer drug target identification

    An integrated approach to predict and validate novel anti-cancer drug targets, with demonstration of strong anti-proliferative effects of predicted targets.

    Genome Medicine 2014, 6:57
  • Image attributed to: Taken from

    Beyond ENCODE?

    In their open peer reviewed correspondence piece, Tagu and colleagues discuss the opportunities afforded by neoENCODE initiatives to understand how genetic systems react in the natural context of living ecosystems. Do comment!

    BMC Genomics 2014, 15:490
  • Motor neuron derivation and application

    Corti and colleagues review the experimental approaches for differentiating human embryonic stem cells and human induced pluripotent stem cells towards functional motor neurons, and summarise their potential clinical applications.

    Stem Cell Research & Therapy 2014, 5:87

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013