Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
A new analysis, utilising new phylogenetically diverse sequences produced by the Avian Genome Consortium, shows that diversification of beta keratin genes has been crucial in the evolution of feathers and the resulting adaptation of birds into multiple niches.
Wang and Chen review how circulating miRNAs can serve as non-invasive biomarkers and therapeutic tools in various cancers, as well as how miRNAs enable communication between cells within the tumor microenvironment.
Single-cell expression analysis maps cellular hierarchy in a mouse acute myeloid leukemia model
In a genome-wide profiling analysis across patients with 19 different diseases, a number of miRNAs found in blood have strong association with disease, emphasizing the potential of circulating miRNAs as minimally invasive diagnostic biomarkers.
To improve the management of cystic fibrosis, a drug repurposing approach was used that incorporated transcription factor and miRNA information to generate feed forward loops and therapeutic suggestions.
News and events
Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'
The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.