Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
Articles
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Genome Medicine 2013, 5:31Microbes in health and disease - a new series
Guest Editor Martin Hibberd highlights advances in genomics, metagenomics and other high-throughput approaches for studying human-microbe interactions in health and disease, and the applications for medicine.
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Genome Biology 2013, 14:204Neurogenomics
From GWAS to Neanderthal genomes: Fisher and Deriziotis review what genomics can teach us about speech, language and their associated disorders
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Genome Medicine 2013, 5:33Cancer isoforms sign off
Expression profiles at the isoform level perform better than those at the gene level to discriminate between cancer cell lines and non-oncogenic cells, regardless of tissue of origin.
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BioData Mining 2013, 6:7Evolutionary algorithms enhance optimal assignment methods
The optimization and visualization of edge weights in optimal assignment methods is a valuable approach for ligandbased virtual screening experiments and provides a useful tool for drug discovery.
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Extreme Physiology & Medicine 2013, 2:8Applying systems biology methods to the study of human physiology in extreme environments
Edwards and Thiele define Systems Biology as "an iterative process of computational model-building and experimental model-revision with the aim of understanding or simulating complex biological systems". Further, they highlight the limited number of physiologically relevant perturbations that are ethically acceptable in humans and highlight the value of environmental and exertional stressors in this context.
News and events
Gigascience - A new open access journal from BioMed Central and BGI
GigaScience, an innovative new journal being launched by BioMed Central and BGI, is now accepting submissions. Edited by Dr Laurie Goodman, GigaScience publishes research relating to biological 'big-data' studies, whilst promoting an integrated database to enable rapid release and permanency of data, and providing a forum for dealing with the difficulties of handling such large-scale data.
Submit your manuscript online, and receive updates on this innovative journal's activities and publications by signing up for alerts.


