Systems Biology Gateway

The knockdown of 78 transcription factors in differentiating human THP-1 cells using matrix RNAi reveals their interdependence

ReTrace finds branching pathways in atom-level representations of genome-scale metabolic networks by considering combinations of the shortest linear pathways, scaling better than constraint-based modeling and avoiding shortfalls of graph-theoretic approaches.

The medical profession needs to re-evaluate the organization of specialties around the populations health care needs in order to adapt to changing requirements and provide better coordinated care for patients with multiple morbidities.

Methods for quantifying cellcell contact often rely on global descriptors, such as overall cell density, but a new statistical model that accounts for local interactions, such as individual cell-cell distances, reduces noisy data and effectively describes contact inhibition effects.

The pH at which proteins are predicted to be most stable relates to the location of their histidine residues, and the average for all proteins in a subcellular compartment correlates closely with local pH.