Systems Biology Gateway

Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.


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  • Image attributed to: Boaworm, CC3.0

    The scale of keratin evolution in birds

    A new analysis, utilising new phylogenetically diverse sequences produced by the Avian Genome Consortium, shows that diversification of beta keratin genes has been crucial in the evolution of feathers and the resulting adaptation of birds into multiple niches.

    BMC Evolutionary Biology 2014, 14:249
  • Circulating miRNAs in cancer

    Wang and Chen review how circulating miRNAs can serve as non-invasive biomarkers and therapeutic tools in various cancers, as well as how miRNAs enable communication between cells within the tumor microenvironment.

    Journal of Hematology & Oncology 2014, 7:86
  • Heterogeneity in leukemia

    Single-cell expression analysis maps cellular hierarchy in a mouse acute myeloid leukemia model

    Genome Biology 2014, 15:525
  • Image attributed to: istock photo

    Circulating miRNAs linked to disease

    In a genome-wide profiling analysis across patients with 19 different diseases, a number of miRNAs found in blood have strong association with disease, emphasizing the potential of circulating miRNAs as minimally invasive diagnostic biomarkers.

    BMC Medicine 2014, 12:224
  • Image attributed to: From Fig 4 Liu et al.

    Feed forward loops for drug repurposing

    To improve the management of cystic fibrosis, a drug repurposing approach was used that incorporated transcription factor and miRNA information to generate feed forward loops and therapeutic suggestions.

    Genome Medicine 2014, 6:94

News and events

Da_Vinci_Vitruvian_man_clip Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'

The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.

Beyond the Genome 2013