Systems Biology Gateway
Welcome to the BioMed Central Systems Biology gateway, highlighting recent articles and news in Systems Biology.
A relationship between disease subtype in chronic lymphocytic leukemia and variation in gene expression suggests that variability has an effect on tumor adaptability and aggressiveness.
Lee Hood and colleagues discuss the benefits of the Hundred Person Wellness Project, a study that aims to monitor 100 ‘well’ individuals, arguing that the results will enable earlier disease intervention to optimize wellness and minimize illness.
The Hundred Person Wellness Project aims to screen healthy individuals to avoid symptomatic disease; Eleftherios Diamandis argues that such testing could lead to over-diagnosis and over-treatment, and should be used with caution.
Current methods to identify pathogens causing diabetic foot infections (DFIs) are inadequate, so Anne Spichler and colleagues suggest that developing new molecular techniques to better understand DFI microbiology will lead to better management of this complex disease.
David Haig speculates on how the work of Andrew Ward and colleagues on the evolutionary implications of the gene imprinting pair Dlk1 and Grb 10, which influence growth regulation antagonistically – at least in mice.
News and events
Cell Communication and Signaling has published a review series on 'Systems Biology and Medicine'
The collection, edited by Fred Schaper and Stephan Feller, provides a comprehensive overview of current models and known networks in signal transduction, including reviews on apoptosis, dopamine metabolism and probabilistic Boolean networks. BioMed Central's magazine Biome published a feature about the series.