Stem Cell Gateway

Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.


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  • Image attributed to: Dhamodoran et al Stem Cell Res Ther ocular stem cell sources

    Cell-based therapy in ophthalmology

    Debashish Das and colleagues review the stem cell populations of the eye and their respective functions in cell-based therapy and regenerative medicine in ophthalmology.

    Stem Cell Research & Therapy 2014, 5:56
  • Image attributed to: Katia Del Rio-Tsonis - a chick eye at E4 (BrdU staining)

    Understanding retinal regeneration

    Following injury of the retinal pigmented epithelium (RPE), dedifferentiation and increased FGF2 expression initiate repair, but Del Rio-Tsonis and colleagues identify the importance of the RNA binding factor Lin28, which can direct the complete reprogramming of the RPE in this regeneration process in the chick eye.

    BMC Biology 2014, 12:28
  • Image attributed to: iStockPhoto xray of arm

    Stem cell therapy for bone repair

    Cynthia Coleman and colleagues review recent advances in the identification, isolation, and mechanism of action of mesenchymal stem cells in bone fracture repair, and discuss their clinical implications.

    Stem Cell Research & Therapy 2014, 5:51
  • Image attributed to: Maternal placental MSCs, Zhu et al Stem Cell Res Ther

    Differences in placental mesenchymal stem cells

    Fetal placental mesenchymal stem cells (MSCs) express higher levels of CD200 and hepatocyte growth factor compared with maternal placental MSCs, and show increased potential for promoting angiogenesis and immunosuppression. 

    Stem Cell Research & Therapy 2014, 5:48
  • Image attributed to: Figure from article, showing mutation signature

    Mutation signatures of carcinogen exposure

    Steven Rozen and colleagues review advances in next-generation sequencing approaches for the detection of mutation signatures of carcinogen exposure, and discuss the implications for cancer prevention.

    Genome Medicine 2014, 6:24
  • Neural stem cells and hydrocephalus

    A review of the potential use of neural stem cells in the treatment of foetal-onset hydrocephalus, a neurological condition involving the abnormal accumulation of cerebrospinal fluid in the brain.

    Fluids and Barriers of the CNS 2014, 11:7
  • Image attributed to: Nasopharynx, wikipedia, Gray's Anatomy, public domain

    Nasopharyngeal cancer stem-like cells

    Pingpin Wei et al. review recent studies on cancer-like stem cells in nasopharyngeal carcinoma, including their isolation, characterisation and therapeutic approaches.

    Stem Cell Research & Therapy 2014, 5:44
  • MSC features of malignant phyllode tumors

    Rare breast phyllodes possess many characteristics of mesenchymal stem cells (MSCs), with aldehyde dehydrogenase and disialoganglioside serving as novel markers for these malignant phyllode tumors.

    Breast Cancer Research 2014, 16:R29
  • Image attributed to: Rojas et al Stem Cell Res Ther, sheep lung diagram

    Adult stem cells for ARDS

    Administration of adult bone marrow-derived stem cells appears to improve lung function, inflammatory response and hemodynamic changes in a sheep model of acute respiratory distress syndrome (ARDS). 

    Stem Cell Research & Therapy 2014, 5:42
  • Image attributed to: Zhang et al Stem Cell Res Ther Oil Red O staining aged MSCs

    Aiding efficacy of aging stem cells

    Sherry Wang and Jun Ren comment on recent research showing that inhibition of IP6Ks turns on Akt signaling, decreases apoptosis, and modulates the paracrine profile in mesenchymal stem cells.

    Stem Cell Research & Therapy 2014, 5:43

News and events

Cardiovascular regeneration series in Stem Cell Research & Therapy

Stem Cell Research & Therapy has issued a call for research submissions for inclusion in a thematic series on cardiovascular regeneration, edited by Ronald Li.

The series will review the current state-of-the-art stem cell-based approaches for disease modelling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions. Authors of commissioned reviews include Kenneth Boheler (National Institutes of Health, USA), Steve Oh (BTI, Singapore) and Sean Wu (Stanford University).

Manuscripts should be submitted online, please indicate in the covering letter that they should be considered for the cardiovascular regeneration series. Any enquiries should be directed to the Stem Cell Research & Therapy editorial office.

Regenerative Medicine Research: a new journal

Regenerative Medicine Research is a new journal that welcomes submissions relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research.

Edited by Y. James Kang, the journal encourages papers from both basic and applied sciences, including the large field of biomedical research in which chronic diseases have become an increasingly prominent area of research, and regenerative medicine has become the first answer of choice.

Manuscripts can be submitted via the online submission system and pre-submission enquiries should be sent to

Hot topics

Tissue engineering


From isolation to implantation: a concise review of mesenchymal stem cell therapy in bone fracture repair


Watson L, Elliman SJ and Coleman CM

Stem Cell Research & Therapy 2014, 5:51

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High expression of 5-hydroxymethylcytosine and isocitrate dehydrogenase 2 is associated with favorable prognosis after curative resection of hepatocellular carcinoma

Liu WR, Tian MX, Jin L, Yang LX, Ding ZB, Shen YH, Peng YF, Zhou J et al.

Journal of Experimental & Clinical Cancer Research 2014, 33:32

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