Stem Cell Gateway

Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.

Articles

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  • DNMT1-related methylation patterns

    DNMT1-dependent and –independent methylation patterns play distinct roles in mouse embryonic stem cell genome stability and transcriptional regulation

    Genome Biology 2015, 16:115
  • ZFP57 in imprinting

    Roles for ZFP57-mediated regulation of genomic imprinting and a novel mechanism for genetically determined mono-allelic gene expression.

    Genome Biology 2015, 16:112
  • Cloning-free CRISPR/Cas system

    Bill Skarnes from Sanger Institute answers a burning question: Is mouse embryonic stem cell technology obsolete?

    Genome Biology 2015, 16:109
  • Image attributed to: from Erdmann and colleagues

    Stem cell fingerprinting

    A robust method for cellular phenotyping in primary human mesenchymal stem cells using kinome fingerprinting to identify gene networks that characterize distinct primary cell populations.

    Genome Medicine 2015, 7:46
  • Image attributed to: de Carvalho et al.

    microRNAs identify neck metastases

    Specific highly expressed microRNAs in lymph nodes identify neck metastases in head and neck squamous cell carcinoma (HNSCC), suggesting these microRNAs could be used as prognostic biomarkers to manage HNSCC patients in the clinical setting.

    BMC Medicine 2015, 13:108
  • Image attributed to: Li et al., BMC Medicine

    Stem cell therapy effective for alopecia

    Stem cell educator therapy, a treatment involving interactions between stem cells and a patient’s own blood cells, stimulates hair growth in alopecia areata (AA) patients, suggesting this novel treatment strategy could be beneficial for AA.

    BMC Medicine 2015, 13:87
  • Sperm chromosome organization

    Comparing chromosome organization in mouse sperm and fibroblasts suggests that packaging chromosomes in sperm does not result in large changes

    Genome Biology 2015, 16:77
  • Colon cancer 5hmC

    Promoters 5-hydroxymethylated during normal colon differentiation are resistant to neoplastic hypermethylation

    Genome Biology 2015, 16:69
  • Managing methylation

    John Greally and colleagues suggest that the use of 5-aza-2'-deoxycytidine may have innate tumorigenic consequences, requiring its cautious use in diseases involving epigenetic dysregulation.

    Epigenetics & Chromatin 2015, 8:11

News and events

Cardiovascular regeneration series in Stem Cell Research & Therapy

Stem Cell Research & Therapy has issued a call for research submissions for inclusion in a thematic series on cardiovascular regeneration, edited by Ronald Li.

The series will review the current state-of-the-art stem cell-based approaches for disease modelling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions. Authors of commissioned reviews include Kenneth Boheler (National Institutes of Health, USA), Steve Oh (BTI, Singapore) and Sean Wu (Stanford University).

Manuscripts should be submitted online, please indicate in the covering letter that they should be considered for the cardiovascular regeneration series. Any enquiries should be directed to the Stem Cell Research & Therapy editorial office.

Regenerative Medicine Research: a new journal

Regenerative Medicine Research is a new journal that welcomes submissions relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research.

Edited by Y. James Kang, the journal encourages papers from both basic and applied sciences, including the large field of biomedical research in which chronic diseases have become an increasingly prominent area of research, and regenerative medicine has become the first answer of choice.

Manuscripts can be submitted via the online submission system and pre-submission enquiries should be sent to regenmedres@biomedcentral.com.

Hot topics

Stem cell niche

Research article

Laminin-rich blood vessels display activated growth factor signaling and act as the proliferation centers in Dupuytren¿s contracture

Viil J, Maasalu K, Mäemets-Allas K, Tamming L, Lõhmussaar K, Tooming M, Ingerpuu S, Märtson A et al.

Arthritis Research & Therapy 2015, 17:144

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Tissue engineering

Research article

Acceleration of bone-defect repair by using A-W MGC loaded with BMP2 and triple point-mutant HIF1α-expressing BMSCs

Gao Y, Li C, Wang H and Fan G

Journal of Orthopaedic Surgery and Research 2015, 10:83

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Epigenetics

Research

The GALNT9, BNC1 and CCDC8 genes are frequently epigenetically dysregulated in breast tumours that metastasise to the brain

Pangeni RP, Channathodiyil P, Huen DS, Eagles LW, Johal BK, Pasha D, Hadjistephanou N, Nevell O et al.

Clinical Epigenetics 2015, 7:57

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