Stem Cell Gateway
Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.
Topical administration of orbital fat-derived stem cells (OFSCs) promotes corneal tissue regeneration in a mouse model of corneal injury through corneal epithelial differentiation of OFSCs and by inhibiting inflammation.
Bone marrow-derived mesenchymal stem cells promote tumor cell proliferation in vitro and tumor growth in vivo, which may be attributed to increased expression of pro-angiogenic factors in the tumor microenvironment.
Mesenchymal stromal cells have potential for clinical application in regenerative medicine, but have varying functional properties owing to donor age and gender, suggesting that identification of these factors are important for clinical use.
Immortalized neural stem cell lines derived from human fetal spinal cord retain their identity after extensive in vitro propagation and differentiate into relevant ventral interneurons and motorneurons.
Combining cyclosporine and adipose-derived stem cell therapy offers improved protection against ischemia-reperfusion-induced acute kidney injury in rats than either therapy alone, with potential clinical relevance in renal transplantation
Jackson and Pepper review the factors in favour of establishing a cell therapy programme in South Africa and the problems which would need to be overcome, such as lack of human resources and funding.
A Research Highlight examines why differentiation in the small intestine crypt bypasses the DNA methylation changes observed in other lineage progressions
Human foetal stem cell grafts improve both motor and sensory functions in rats suffering from a spinal cord injury, demonstrating potential for cell replacement therapy in human spinal cord injuries.
Intriguingly, DNA methylation in mouse intestinal cells does not change much during differentiation
Mesenchymal stem cells (MSCs), which could be used as vehicles for anti-cancer agents owing to tumor homing properties, have different migration and recruitment capacities dependent on their lineages, suggesting that clinical characterization to ensure efficacy and safety is vital.
News and events
Clinical applications of stem cells
Stem Cell Research & Therapy has published the first articles in a new thematic series on clinical applications of stem cells and is now inviting research submissions for the series. For more information read the introductory editorial from Series Editor Mahendra Rao (National Institutes of Health, USA), or the related blog post.
Cell Regeneration has published its first set of high quality research articles with BioMed Central. It welcomes novel research articles as well as in depth reviews in modern biology, especially in the field of stem cell and regenerative biology, and regenerative medicine. The journal is supported by Guangzhou Institute of Biomedicine and Health, which covers APCs for all authors. In the launch issue it presented novel approaches to grow cells in vitro or ideas that may eventually help us to regenerate cell or tissues in vivo. Read more at the launch blog.
Focus on Stem Cells - a new thematic series
The explosion of interest in stem cells, over the past decade or so, in both basic and translational research has encouraged three of BioMed Central's flagship journals, BMC Biology, BMC Medicine and Genome Medicine, to come together to present a series of specially commissioned comment and review articles on stem cell biology and medicine. In this thematic series we aim to highlight some of the most important and topical issues - including recent advances, controversies and challenges in stem cell research, and of course their clinical implications. To supplement the comment and review, relevant original research articles will be added to the series as they are published.
Stem cell niche
Stem Cell Research & Therapy 2013, 4:64
BMC Oral Health 2013, 13:27
BMC Medical Genomics 2013, 6:21