Stem Cell Gateway

Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.


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  • Colon cancer 5hmC

    Promoters 5-hydroxymethylated during normal colon differentiation are resistant to neoplastic hypermethylation

    Genome Biology 2015, 16:69
  • Managing methylation

    John Greally and colleagues suggest that the use of 5-aza-2'-deoxycytidine may have innate tumorigenic consequences, requiring its cautious use in diseases involving epigenetic dysregulation.

    Epigenetics & Chromatin 2015, 8:11
  • Firre anchors X chromosome

    lncRNA Firre helps anchor the inactive X chromosome to a specific nuclear compartment and maintain its heterochromatic structure

    Genome Biology 2015, 16:52
  • Image attributed to: istock

    Tumor microenvironment insights 

    Fei Chen and colleagues discuss the role of the tumor microenvironment (TME) in cancer progression, highlighting ways in which the TME can be targeted to improve therapeutic efficacy and reduce resistance in a personalized approach to cancer therapy. 

    BMC Medicine 2015, 13:45
  • m6A regulates pluripotency

    He and Zhao discuss a recent study showing that m6A has a crucial function in regulating pluripotency in murine stem cells

    Genome Biology 2015, 16:43
  • Using epigenetics to classify leukemias

    A new DNA methylation-based method for subtype prediction of pediatric acute lymphoblastic leukemia.

    Clinical Epigenetics 2015, 7:11
  • CRC's linear progression

    An analysis of the primary and metastatic colorectal cancers with liver-limited metastases suggests linear progression

    Genome Biology 2015, 16:32
  • Regulating flowering time

    A complex network involving the transcription factors SHORT VEGETATIVE PHASE and FLOWERING LOCUS C, regulates flowering initiation in Arabidopsis

    Genome Biology 2015, 16:31
  • Image attributed to: Detail of Figure 1_from Charlton et al.

    Epigenetic biomarkers of Wilms tumour

    Methylome analysis of wilms tumors, nephrogenic rests and normal kidney tissues provides insight into tumor evolution and reveals potential markers to diagnose patients with bilateral disease.

    Genome Medicine 2015, 7:11

News and events

Cardiovascular regeneration series in Stem Cell Research & Therapy

Stem Cell Research & Therapy has issued a call for research submissions for inclusion in a thematic series on cardiovascular regeneration, edited by Ronald Li.

The series will review the current state-of-the-art stem cell-based approaches for disease modelling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions. Authors of commissioned reviews include Kenneth Boheler (National Institutes of Health, USA), Steve Oh (BTI, Singapore) and Sean Wu (Stanford University).

Manuscripts should be submitted online, please indicate in the covering letter that they should be considered for the cardiovascular regeneration series. Any enquiries should be directed to the Stem Cell Research & Therapy editorial office.

Regenerative Medicine Research: a new journal

Regenerative Medicine Research is a new journal that welcomes submissions relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research.

Edited by Y. James Kang, the journal encourages papers from both basic and applied sciences, including the large field of biomedical research in which chronic diseases have become an increasingly prominent area of research, and regenerative medicine has become the first answer of choice.

Manuscripts can be submitted via the online submission system and pre-submission enquiries should be sent to

Hot topics

Stem cell niche


Long-term culture and significant expansion of human Sertoli cells whilst maintaining stable global phenotype and AKT and SMAD1/5 activation

Guo Y, Hai Y, Yao C, Chen Z, Hou J, Li Z and He Z

Cell Communication and Signaling 2015, 13:20

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Tissue engineering


Tensile properties of the rectal and sigmoid colon: a comparative analysis of human and porcine tissue

Christensen MB, Oberg K and Wolchok JC

SpringerPlus 2015, 4:142

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Research article

Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

Lehmann BD, Ding Y, Viox DJ, Jiang M, Zheng Y, Liao W, Chen X, Xiang W et al.

BMC Cancer 2015, 15:179

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