Stem Cell Gateway

Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.

Articles

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Umbilical cord stem cells for IVD therapy?

Human umbilical cord stem cells can differentiate into cells exhibiting an immature nucleus pulposus phenotype in a laminin-rich culture environment, and may have therapeutic potential in intervertebral disc (IVD) degeneration.

Stem Cell Research & Therapy 2013, 4:120
Identifying gaps in breast cancer research

Current knowledge 'gaps' in the understanding of breast cancer are examined, and research should focus on these to improve future clinical care.

Breast Cancer Research 2013, 15:R92
iPS and tumor cell response to genotoxins

ATM and p53 phosphorylation are differentially regulated in human induced pluripotent stem cells compared with Tera-1 and BEAS-2B cells after exposure to chromium, providing insight into how iPS cells maintain their genomic integrity

Journal of Hematology & Oncology 2013, 6:71
Cancer cells: secreted factors affect MSCs

Cancer cells may transform mesenchymal stem cells (MSCs) into pro-inflammatory cells through the secretion of factors such as interleukin-1β, thus promoting cancer progression.

Stem Cell Research & Therapy 2013, 4:114
7SK: transcriptional regulator

A study in ESCs finds that 7SK promotes transcriptional termination and poising, and regulates bidirectional transcription

Genome Biology 2013, 14:r98
Promoting wound healing with stem cells

Mesenchymal stem cells modified with angiopoietin-1 accelerated wound healing in rats by promoting skin regeneration and angiogenesis, with potential clinical applications in chronic wound therapy.

Stem Cell Research & Therapy 2013, 4:113
HSPC and MSC cell signaling receptors

Bone marrow-derived hematopoietic stem/progenitor cells (HSPCs) and mesenchymal stem cells (MSCs) have different molecular receptor signaling transcript profiles linked to cell survival, growth, mobility and differentiation potential.

Stem Cell Research & Therapy 2013, 4:112
MSCs affect MM Cells via Fas

Mesenchymal stem cells (MSCs) induce apoptosis of multiple myeloma (MM) cells via Fas-ligand (Fas-L) and levels of Fas-L expression determine, at least partially, the effect of MSCs on cancer growth.

Stem Cell Research & Therapy 2013, 4:111
Microspheres for neural cell delivery

Collagen microspheres can support the growth and differentiation of oligodendrocyte progenitor cells and have potential for the delivery of neural progenitor cells for neural regeneration.

Stem Cell Research & Therapy 2013, 4:109
miR-21 as an oncogenic regulator

Hong-Yo Kang comments on recent research showing microRNA-21 (miR-21) promotes ovarian teratocarcinoma cell growth by sustaining cancer stem/progenitor populations, and whether targeting miR-21 might be a novel therapeutic approach in cancer.

Stem Cell Research & Therapy 2013, 4:110

News and events

Cardiovascular regeneration series in Stem Cell Research & Therapy

Stem Cell Research & Therapy has issued a call for research submissions for inclusion in a thematic series on cardiovascular regeneration, edited by Ronald Li.

The series will review the current state-of-the-art stem cell-based approaches for disease modelling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions. Authors of commissioned reviews include Kenneth Boheler (National Institutes of Health, USA), Steve Oh (BTI, Singapore) and Sean Wu (Stanford University).

Manuscripts should be submitted online, please indicate in the covering letter that they should be considered for the cardiovascular regeneration series. Any enquiries should be directed to the Stem Cell Research & Therapy editorial office.

Regenerative Medicine Research is accepting submissions

Regenerative Medicine Research is a new journal that welcomes submissions relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research.

Edited by Y. James Kang, the journal encourages papers from both basic and applied sciences, including the large field of biomedical research in which chronic diseases have become an increasingly prominent area of research, and regenerative medicine has become the first answer of choice.

Manuscripts can be submitted via the online submission system and pre-submission enquiries should be sent to regenmedres@biomedcentral.com.