Stem Cell Gateway
Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.
Debashish Das and colleagues review the stem cell populations of the eye and their respective functions in cell-based therapy and regenerative medicine in ophthalmology.
Following injury of the retinal pigmented epithelium (RPE), dedifferentiation and increased FGF2 expression initiate repair, but Del Rio-Tsonis and colleagues identify the importance of the RNA binding factor Lin28, which can direct the complete reprogramming of the RPE in this regeneration process in the chick eye.
Cynthia Coleman and colleagues review recent advances in the identification, isolation, and mechanism of action of mesenchymal stem cells in bone fracture repair, and discuss their clinical implications.
Fetal placental mesenchymal stem cells (MSCs) express higher levels of CD200 and hepatocyte growth factor compared with maternal placental MSCs, and show increased potential for promoting angiogenesis and immunosuppression.
Steven Rozen and colleagues review advances in next-generation sequencing approaches for the detection of mutation signatures of carcinogen exposure, and discuss the implications for cancer prevention.
A review of the potential use of neural stem cells in the treatment of foetal-onset hydrocephalus, a neurological condition involving the abnormal accumulation of cerebrospinal fluid in the brain.
Pingpin Wei et al. review recent studies on cancer-like stem cells in nasopharyngeal carcinoma, including their isolation, characterisation and therapeutic approaches.
Rare breast phyllodes possess many characteristics of mesenchymal stem cells (MSCs), with aldehyde dehydrogenase and disialoganglioside serving as novel markers for these malignant phyllode tumors.
Administration of adult bone marrow-derived stem cells appears to improve lung function, inflammatory response and hemodynamic changes in a sheep model of acute respiratory distress syndrome (ARDS).
Sherry Wang and Jun Ren comment on recent research showing that inhibition of IP6Ks turns on Akt signaling, decreases apoptosis, and modulates the paracrine profile in mesenchymal stem cells.
News and events
Stem Cell Research & Therapy has issued a call for research submissions for inclusion in a thematic series on cardiovascular regeneration, edited by Ronald Li.
The series will review the current state-of-the-art stem cell-based approaches for disease modelling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions. Authors of commissioned reviews include Kenneth Boheler (National Institutes of Health, USA), Steve Oh (BTI, Singapore) and Sean Wu (Stanford University).
Manuscripts should be submitted online, please indicate in the covering letter that they should be considered for the cardiovascular regeneration series. Any enquiries should be directed to the Stem Cell Research & Therapy editorial office.
Regenerative Medicine Research is a new journal that welcomes submissions relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research.
Edited by Y. James Kang, the journal encourages papers from both basic and applied sciences, including the large field of biomedical research in which chronic diseases have become an increasingly prominent area of research, and regenerative medicine has become the first answer of choice.
Stem cell niche
BMC Genomics 2014, 15:277
Stem Cell Research & Therapy 2014, 5:51
Journal of Experimental & Clinical Cancer Research 2014, 33:32