Stem Cell Gateway

Welcome to the BioMed Central Stem Cell Gateway, highlighting the latest articles we have published in the stem cell field. Content is continually updated, so please bookmark this page and ensure you check it regularly.


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  • Image attributed to: digital globe

    Engineering epigenomes

    Anna Köferle, Stefan Stricker, and Stephan Beck discuss targeted epigenome engineering, and the brave new world that has such technologies in't.

    Genome Medicine 2015, 7:59
  • MicroRNA insights into mammary biology

    miRNA expression profiles of distinct epithelial subpopulations and comparison to gene expression and epigenetic information shed light on the role of miRNA and the epigenome in mammary cell differentiation and oncogenesis.

    Breast Cancer Research 2015, 17:85
  • Circular RNA detection

    A new algorithm detects circular RNAs with high sensitivity and specificity and discovers human fetal brain regions enriched for circular RNA isoforms

    Genome Biology 2015, 16:126
  • Single cell transcriptomics

    Single-cell RNA sequencing data provide a unique view of transcriptome function

    Genome Biology 2015, 16:122
  • Image attributed to: From Fig 3 Xue and colleagues

    CRISPR-Cas9 cancer mouse models

    Wen Xue and colleagues review the recent progress in using genome editing techniques, particularly CRISPR-Cas9, to efficiently develop mouse models of cancer and leukemia.

    Genome Medicine 2015, 7:53
  • DNMT1-related methylation patterns

    DNMT1-dependent and –independent methylation patterns play distinct roles in mouse embryonic stem cell genome stability and transcriptional regulation

    Genome Biology 2015, 16:115
  • ZFP57 in imprinting

    Roles for ZFP57-mediated regulation of genomic imprinting and a novel mechanism for genetically determined mono-allelic gene expression.

    Genome Biology 2015, 16:112
  • Image attributed to: Flickr by Ed Uthman

    Marker for periampullary adenocarcinoma prognosis

    An immunohistochemical study demonstrates that podocalyxin-like protein expression is associated with more aggressive tumor phenotype and poor prognosis in pancreatic, distal bile duct, ampullary and duodenal adenocarcinoma.

    BMC Clinical Pathology 2015, 15:10
  • Cloning-free CRISPR/Cas system

    Bill Skarnes from Sanger Institute answers a burning question: Is mouse embryonic stem cell technology obsolete?

    Genome Biology 2015, 16:109
  • Image attributed to: from Erdmann and colleagues

    Stem cell fingerprinting

    A robust method for cellular phenotyping in primary human mesenchymal stem cells using kinome fingerprinting to identify gene networks that characterize distinct primary cell populations.

    Genome Medicine 2015, 7:46

News and events

Cardiovascular regeneration series in Stem Cell Research & Therapy

Stem Cell Research & Therapy has issued a call for research submissions for inclusion in a thematic series on cardiovascular regeneration, edited by Ronald Li.

The series will review the current state-of-the-art stem cell-based approaches for disease modelling, drug discovery and myocardial repair, as well as the associated hurdles and potential solutions. Authors of commissioned reviews include Kenneth Boheler (National Institutes of Health, USA), Steve Oh (BTI, Singapore) and Sean Wu (Stanford University).

Manuscripts should be submitted online, please indicate in the covering letter that they should be considered for the cardiovascular regeneration series. Any enquiries should be directed to the Stem Cell Research & Therapy editorial office.

Regenerative Medicine Research: a new journal

Regenerative Medicine Research is a new journal that welcomes submissions relating to both the fundamental and practical aspects of regenerative medicine, with a particular emphasis on translational research.

Edited by Y. James Kang, the journal encourages papers from both basic and applied sciences, including the large field of biomedical research in which chronic diseases have become an increasingly prominent area of research, and regenerative medicine has become the first answer of choice.

Manuscripts can be submitted via the online submission system and pre-submission enquiries should be sent to

Hot topics

Stem cell niche


Biological behavior of mesenchymal stem cells on poly-¿-caprolactone filaments and a strategy for tissue engineering of segments of the peripheral nerves

Carrier-Ruiz A, Evaristo-Mendonça F, Mendez-Otero R and Ribeiro-Resende VT

Stem Cell Research & Therapy 2015, 6:128

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Tissue engineering

Research article

Severe mutilating injuries with complex macroamputations of the upper extremity ¿ is it worth the effort?

Stanger K, Horch RE and Dragu A

World Journal of Emergency Surgery 2015, 10:30

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