RNAi Gateway

An approach to identifying the physiological targets of ubiquitin receptors and the biological circuits they regulate is validated by screening for genes whose overexpression slows the growth of yeast cells lacking the ubiquitin-binding proteins Rad23 and Dsk2

Phenanthridine derived polyADP-ribose polymerase (PARP) inhibitors originally designed to protect cells from cell-death under stress conditions efficiently eradicate breast cancer cells without impairing normal proliferating or non-proliferating cells.

A major genome-wide transposon mutagenesis screen in the red flour beetle sets the scene for future genetic analyses in this increasingly important model organism, and the same screening procedure can be potentially applied to other insects.

The knockdown of 78 transcription factors in differentiating human THP-1 cells using matrix RNAi reveals their interdependence

The antiproliferative effects of vitamin D on a breast tumour cell line persist despite knockdown of the vitamin D receptor gene, and variants resistant to these anti-proliferative effects do not show changes in known vitamin D signaling pathway genes.