Welcome to BioMed Central's Respiratory Gateway, highlighting the latest articles we have published in this field. Content is continually updated, so please bookmark this page and ensure you check it regularly.
Randomized trials are not always the best way to ascertain the benefit of medical interventions; Milo Puhan and colleagues argue that quantitative benefit-herm assessments should be used to guide further research, discussing rofilumast as an example.
Benjamin Marsland and Olawale Salami discuss how advances in understanding the airway microbiome and its link to disease is changing the respiratory disease field and generating new leads for therapy.
In a systematic review and meta-analysis, anti-PCSK9 antibodies reduce LDL cholesterol, increase HDL cholesterol, and are well-tolerated, suggesting that these drugs have a beneficial effect on lipid profiles and could reduce cardiovascular risk.
The tumour suppressor APC plays a critical role in cancer growth, largely through its negative regulation of the Wnt pathway. Shi and colleagues investigate the role of APC in mesenchymal cells in the developing lung, and find surprising results in both the breadth and downstream effects of APC’s dysregulation.
A single-cell transcriptomic analysis of lung adenocarcinoma patient derived xenografts reveals heterogeneity in the response to anti-cancer drugs
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